Sort   by:  
 Page size 
MetabolomicsDifferential expression of Transcriptomics and Metabolomics in different developmental periods of poria cocos

Poria cocos, a traditional medicinal fungus, exhibits a wide array of biological activities. Through the integration of metabolomic and transcriptomic analyses, we have determined that the development of Poria cocos mycelia is predominantly propelled by biochemical reactions triggered by oxidativ...

2025-03-26 | MTBLS11738 | MetaboLights
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
MetabolomicsMulti-omics analysis of differential expression profiles in Vibrio natriegens strain VCOD-2 under optimal and high-salinity conditions

This study employs integrated multi-omics analysis to systematically investigate the proteome and metabolome of marine bacterium Vibrio natriegens strain VCOD-2 (ATCC 14048) under optimal salinity (3% NaCl) and high-salinity stress (8% NaCl) conditions, aiming to reveal the molecular me...

2026-03-18 | MTBLS14070 | MetaboLights
MetabolomicsSystematic identification of metabolites controlling gene expression in E. coli
Metabolism controls gene expression through allosteric interactions between metabolites and transcription factors. These interactions are usually measured with in vitro assays, but there are no methods to identify them at a genome-scale in vivo. Here we show that dynamic transcriptome and metabolome...
2019-08-23 | MTBLS1044 | MetaboLights
MetabolomicsMolecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

Sweet cherry (Prunus avium L.) is a stone fruit widely consumed and appreciated for its organoleptic properties, as well as its nutraceutical potential. We here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Ba...

2021-10-29 | MTBLS1803 | MetaboLights
MetabolomicsSimilar, but different: structurally related azelaic acid and hexanoic acid trigger differential metabolomic and transcriptomic responses in tobacco cells
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza...
2018-10-17 | MTBLS559 | MetaboLights
MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
MetabolomicsIn-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. However, single-cell metabolomics remains challenging because of the limited metabolite coverage and inability to discriminate is...
2026-08-14 | MTBLS8113 | MetaboLights
MetabolomicsDifferential alteration of plant functions by homologous fungal candidate effectors

Rust fungi are plant pathogens that cause epidemics which threatens the production of many important plant species, such as wheat, soy, coffee and poplar. Melampsora larici-populina (Mlp) causes the poplar rust and encodes at least 1184 candidate effectors (CEs), however their functions are poorl...

2020-12-03 | MTBLS2096 | MetaboLights
MetabolomicsMelatonin enhances function of porcine immature Sertoli cells via modulating gene expression and metabolism

Melatonin (MT), a neurohormone synthesized and secreted primarily by the pineal gland, is of vital function to animal reproduction. However, the effect of MT treatment on porcine immature Sertoli cells (iSCs) remains unclear. Here, MT treatment (10 nM, 36 h) could elevate mitochondrial function a...

2025-01-06 | MTBLS11126 | MetaboLights
Sort   by:  
 Page size