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TranscriptomicsRNA sequencing analysis of DAF-16 target gene expression when math-33 function is genetically inactivated
In this study we have investigated the effect of loss of math-33 activity on DAF-16-mediated target gene regulation in C. elegans under conditions of reduced Insulin/IGF-1 signaling (IIS). Using whole nematode RNA sequencing experiments we found that the daf-2(e1370)-mediated induction and repressio...
ORGANISM(S): Caenorhabditis elegans 
2016-06-22 | E-GEOD-70117 | biostudies-arrayexpress
TranscriptomicsAMPK and calcineurin induced longevity is mediated by CRTC-1 and CREB
AMPK (AAK-2) and calcineurin (TAX-6) mediate longevity exclusively through post-translational modification of CRTC-1, the sole C. elegans CRTC (CREB regulated transcriptional coactivator). We performed microarrays to examine the transcriptional responses elicited by the pro-longevity: activation of ...
ORGANISM(S): Caenorhabditis elegans 
2010-11-20 | E-GEOD-25513 | biostudies-arrayexpress
TranscriptomicsLipid biosynthesis coordinates a Mitochondrial to Cytosolic Stress Response
Defects in mitochondrial metabolism have been increasingly linked with age-onset protein misfolding diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. In response to protein folding stress, compartment-specific unfolded protein responses (UPRs) within the endoplasmic reticulum, mitoc...
ORGANISM(S): Caenorhabditis elegans 
2016-09-08 | E-GEOD-83722 | biostudies-arrayexpress
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