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ModelsBoehm2014 - isoform-specific dimerization of pSTAT5A and pSTAT5B
Boehm2014 - isoform-specific dimerization of pSTAT5A and pSTAT5B To study STAT5 activation, the authors build a dynamic model of pSTAT5 isoform dimerization. Combinatorial binding of pSTAT5A and pSTAT5B is analysed using model hypotheses and concurrent experiments. Model parameters are derived from ...
2024-09-02 | BIOMD0000000591 | BioModels
TranscriptomicsPrednisolone-induced differential gene expression in liver of mice carrying the wild type or a dimerization-defective glucocorticoid receptor
Glucocorticoids control expression of a large number of genes after binding to the glucocorticoid receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although th...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21048 | biostudies-arrayexpress
GenomicsGlucocorticoid eceptor dimerization in tumorigenesis
Glucocorticoid eceptor dimerization in tumorigenesis
PRJNA1425796 | ENA
GenomicsFunctional characterization of androgen receptor dimerization interfaces [ChIP-seq]
Functional characterization of androgen receptor dimerization interfaces [ChIP-seq]
PRJNA1471273 | ENA
GenomicsFunctional characterization of androgen receptor dimerization interfaces [STARR-seq]
Functional characterization of androgen receptor dimerization interfaces [STARR-seq]
PRJNA1471272 | ENA
GenomicsFunctional characterization of androgen receptor dimerization interfaces [RNA-seq]
Functional characterization of androgen receptor dimerization interfaces [RNA-seq]
PRJNA1471274 | ENA
GenomicsAR dimerization surface mutants and wt in PC3 cells
AR dimerization surface mutants and wt in PC3 cells
PRJNA865559 | ENA
TranscriptomicsGene Regulation by the Human Glucocorticoid Receptor Dimerization Domain Mutant dim4
A mutation in the dimerization domain of the mouse glucocorticoid receptor (GR), dim1, has recently been shown to bind DNA and regulate gene expression. To expand these studies we created a stable osteosarcoma (U-2 OS) cell line expressing four mutations in the dimerization domain of the human GR, ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26857 | biostudies-arrayexpress
TranscriptomicsControlled ErbB receptor dimerization
In order to better understand signaling events following receptor dimerization involving HER2, we have generated an experimental system in which ErbB dimerization can be controlled. We used gene expression microarrays to identify genes and pathways that are differentially activated by HER2 homodimer...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22288 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in murine hearts treated with an ERK-dimerization inhibitory peptide gene therapy or control after transverse aortic constriction
This study identifies gene expression changes in murine hearts after TAC surgery and in response to gene therapy with ERK-dimerization inhibitory peptide
ORGANISM(S): Mus musculus 
2020-02-03 | E-MTAB-8110 | biostudies-arrayexpress
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