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TranscriptomicsGene expression profiling of advanced murine K-RasG12V lung adenocarcinomas
We aimed to analyze the transcriptional profile of full-blown murine lung adenocarcinomas driven by K-RasG12V oncogene. We used a GEM model of lung adenocarcinoma driven by a resident K-RasG12V oncogene. On average, tumors were collected 10 months after Adeno-CRE infection.
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65257 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of normal lung cells and K-RasG12V driven hyperplasias
We aimed to analyze the transcriptional profile of lung epithelial cells early after the expression of a resident K-RasG12V oncogene. This approach was based on the rationale that valuable therapeutic targets should be easier to detect in the first stages of tumor development due to tumor heterogene...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-65256 | biostudies-arrayexpress
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
UnknownA global thermodynamic-kinetic model capturing the hallmarks of liquid-liquid phase separation and amyloid aggregation
Not available
S-EPMC12927656 | biostudies-literature
UnknownA Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation.
Not available
S-EPMC12154704 | biostudies-literature
UnknownSAM recognition and conformational switching mechanism in the Bacillus subtilis yitJ S box/SAM-I riboswitch.
Not available
S-EPMC3222078 | biostudies-literature
GenomicsL3MBTL2 protein acts in concert with PcG protein mediated monoubiquitination of H2A to establish a repressive chromatin structure [ChIP-Seq data].
Human MBT domain-containing protein L3MBTL2 was found to be an integral component of a protein complex that we termed Polycomb Repressive Complex 1-like 3 (PRC1L3) given the presence of the PcG proteins RING1, RING2 and PCGF6. L3MBTL2 binds chromatin in a histone modification-independent manner and ...
ORGANISM(S): Homo sapiens 
2011-06-07 | E-GEOD-28162 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
UnknownMitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis.
Not available
S-EPMC6411938 | biostudies-literature
UnknownClinical characteristics and early prediction of mortality risk in patients with acute organophosphate poisoning-induced shock.
Not available
S-EPMC9874994 | biostudies-literature
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