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ProteomicsThe cellular and proteomic response of primary and immortalized murine Kupffer cells following immune stimulation diverges from that of monocyte-derived macrophages
Kupffer cells are the first line of defense in the liver against pathogens, yet several microbes successfully target the liver, bypass immune surveillance, and effectively develop in this tissue. Our current, albeit poor, understanding of Kupffer cell-pathogen interactions has been largely achieved ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079995 | MassIVE
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079959 | MassIVE
ProteomicsThe cellular and proteomic response of primary and immortalized murine Kupffer cells following immune stimulation diverges from that of monocyte-derived macrophages
Kupffer cells are the first line of defense in the liver against pathogens, yet several microbes successfully target the liver, bypass immune surveillance, and effectively develop in this tissue. Our current, albeit poor, understanding of Kupffer cell-pathogen interactions has been largely achieved ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-03 | PXD001247 | Pride
Cytoskeleton  kupffer cell  macrophage  malaria  murine 
ProteomicsRibosomal/nucleolar stress induction regulates tert-butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts
A general understanding of redox homeostasis in An. gambiae midgut epithelial cells under different oxidative conditions during P. falciparum ookinete invasion is missing. We used an ex vivo midgut culture model to understand AgTrx-1 protein expression pattern in An. gambiae midguts under oxidative ...
ORGANISM(S): Anopheles gambiae (African malaria mosquito) 
2018-11-21 | PXD008251 | Pride
Malaria Tert butyl hydroperoxide Ribosomal stress Anopheles gambiae Nucleolar stress Oxidative stress 
ProteomicsSex-partitioning of the Plasmodium falciparum gametocyte proteome provides insight into falciparum-specific cell biology
Plasmodium falciparum gametocyte stages represent a small fraction of the entire parasite biomass that is present during human malaria infection, yet they alone lead to the transmission of this devastating disease. One of the critical gaps in malaria transmission biology and surveillance is our lack...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2014-07-25 | PXD000813 | Pride
Gametocyte Mass spectrometry Bioinformatics Malaria Proteomics Sexual stages 
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo sapiens (Human) 
2014-02-17 | PXD000682 | Pride
Host-pathogen interaction Mass spectrometry Emt Human hepatocellular carcinoma Transcriptomics Malaria Proteomics 
ProteomicsParaquat mediated oxidative stress in Anopheles gambiae mosquitoes is regulated by an endoplasmic reticulum (ER) stress response
A deeper understanding of malaria parasite development inside the Anopheles mosquito may lead to the identification of processes that can be targeted by transmission-blocking interventions. Paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride) is a potent superoxide-inducing agent that impacts Plasm...
ORGANISM(S): Anopheles gambiae (African malaria mosquito) 
2022-03-01 | PXD008231 | Pride
Malaria  anopheles gambiae  oxidative stress  endoplasmic reticulum stress  paraquat  transmission-blocking. 
ProteomicsP.falciparum - Whole organism, Dd2, SC (Tao,mcp,2014)
abundance based on Spectral counting, Dd2, Interaction consistency score: 2.8, Coverage: 81
ORGANISM(S): 5833 
2014-00-00 | 3453092459 | PAXDB
ProteomicsP.falciparum - Whole organism, Girbc, SC (Tao,mcp,2014)
abundance based on Spectral counting, GiRBC, Interaction consistency score: 2.9, Coverage: 88
ORGANISM(S): 5833 
2014-00-00 | 3294826571 | PAXDB
OtherA bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites
PXD ID: PXD000062, experiment: GambiaeOG3, data file: gambiaef11.mzxml. Data published as part of Mol Cell Proteomics. 2012 Oct 17 .From the Abstract: {{i}}... Plasmodium parasites are transmitted by Anopheles mosquitoes and the critical site of interaction is at the mosquito"s luminal midgut brush...
ORGANISM(S): Mosquito 
GPM11210007339 | GPMDB
Resource Reanalysis 
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