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MetabolomicsMicrobial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut
Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation and integrity of the intestinal epithelium. However, the production of SCFAs can vary widely between individuals consuming the same diet, with lower levels often associated ...
2026-05-26 | MTBLS2308 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
MetabolomicsOmics data integration allows the identification of an idiopathic Parkinson’s disease signature
The vast majority of Parkinson’s disease cases are idiopathic. Unclear ethiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent across different idiopathic Parkinson’s disease (IPD) patients ...
2026-03-16 | MTBLS7740 | MetaboLights
MetabolomicsMetabolic memory underlying minimal residual disease in breast cancer

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here we integrated multi-omics data from a tractable organoid system with a metabol...

2021-09-14 | MTBLS1507 | MetaboLights
MetabolomicsUntargeted Plasma Lipidomics Identifies Oxidative Stress and Inflammation Signatures Associated with Recurrent Leg Ulcer Status in Sickle Cell Disease

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
UnknownA primer on multiscale modelling of infectious disease systems.
Not available
S-EPMC6326222 | biostudies-literature
GenomicsMaturation of human cardiac organoids enables complex disease modelling and drug discovery
Maturation of human cardiac organoids enables complex disease modelling and drug discovery
PRJNA1211166 | ENA
GenomicsReproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (passages)
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (passages)
PRJNA1213756 | ENA
GenomicsReproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (timepoints)
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (timepoints)
PRJNA1121199 | ENA
GenomicsModelling G2019S-LRRK2 sporadic Parkinson’s disease in 3D midbrain organoids
Modelling G2019S-LRRK2 sporadic Parkinson’s disease in 3D midbrain organoids
PRJNA515615 | ENA
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