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MetabolomicsExcoriation Disorder Is Characterized by Systemic Glutamatergic Dysfunction

Excoriation disorder (ED), also known as neurotic excoriations, is a psychocutaneous disorder characterized by repetitive, compulsive picking of the skin leading to secondary tissue damage. ED carries an estimated prevalence of 1.4%, and is associated with significant social dysfunction, as patie...

2024-04-03 | MTBLS9118 | MetaboLights
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
MetabolomicsGut Microbiota and Urine Metabolomics Signature in Autism Spectrum Disorder children from Southern China

To determine the gut microbiota and urine metabolomics signature and identify the regional characteristics in Autism spectrum disorder (ASD), we conducted a cohort study of 88 well-characterized participants from Guangxi Zhuang Autonomous Region in Southern China. Gut microbiota and urine metabo...

2025-06-16 | MTBLS12605 | MetaboLights
MetabolomicsMetabolic abnormalities of the cortico-striato-thalamo-cortical circuit of rats with tic disorder

Tic disorder (TD) is a developmental neuropsychiatric disorder that primarily occurs during childhood and impacts the quality of life and psychosocial function of patients. The pathogenesis of TD involves the dysregulation of the cortico-striato-thalamo-cortical (CSTC) circuit and metabolic abnor...

2025-03-18 | MTBLS11764 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine
Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and mic...
2026-08-20 | MTBLS10141 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine

Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and ...

2026-08-20 | MTBLS10145 | MetaboLights
MetabolomicsWlingsan ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2026-08-26 | MTBLS14691 | MetaboLights
MetabolomicsHuanglianjiedu Decoction ameliorates high-fat diet-induced lipid metabolism disorder
In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molecula...
2026-08-26 | MTBLS14701 | MetaboLights
MetabolomicsYinchenhao Decoction ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2027-06-26 | MTBLS14689 | MetaboLights
MetabolomicsMetabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy

OBJECTIVE: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune-mediated neuropathy. Although microbial infection is potentially a contributing factor, a causative link between CIDP and microbial infection remains unclear. There is also no de...

2023-01-16 | MTBLS5828 | MetaboLights
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