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ProteomicsFast and Accurate Disulfide Bridge Detection
Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a multi-billion-dollar industry. Essential here is quality control assessment of critical attributes such as sequence fidelity, proper folding, and post-translational modifications (PTMs). Errors can lead to di...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD046855 | Pride
Faims Disulfide Ethcd Mab Scrambling 
ProteomicsIntramolecular disulfide bridges in Voltage-Dependent Anion Channel 2 (VDAC2) protein from Rattus norvegicus revealed by high resolution mass spectrometry.
Voltage-Dependent Anion Channel isoforms (VDAC1, VDAC2, VDAC3) are relevant component of the outer mitochondrial membrane and play crucial role in cellular processes, in regulation of metabolism and in survival pathways. Recently, we reported the characterization of the oxidation pattern of cysteine...
ORGANISM(S): Rattus rattus (Black rat) 
2024-06-16 | PXD044041 | Pride
High-resolution mass spectrometry  intramolecular disulfide bridges  rattus voltage-dependent anion selective channel isoform 2 (rvdac2)  cysteine redox state  structural characterization. 
UnknownRole of the Conserved Disulfide Bridge in Class A Carbapenemases.
Not available
S-EPMC5063999 | biostudies-literature
ProteomicsA2M Thr654Cys Thr661Cys mutant disulfide mapping
The Thr654Cys and Thr661Cys mutations were used to introduce a disulfide bridge into the interacting LNK domains of human A2M. In this study, formation of the disulfide was investigated by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2021-05-21 | PXD019081 | Pride
Human a2m disulfide mutant 
UnknownDisulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.
Not available
S-EPMC6457126 | biostudies-literature
UnknownBovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge.
Not available
S-EPMC4018250 | biostudies-literature
UnknownModulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications.
Not available
S-EPMC10909431 | biostudies-literature
ProteomicsStructural characterization of intra- and intermolecular disulfide bonds in Voltage-Dependent Anion Channel 3 (VDAC3) protein from Rattus norvegicus by high-resolution mass spectrometry
Voltage-Dependent Anion Channels, the most abundant proteins of the mitochondrial outer membrane, are responsible for exchange of ions and metabolites between cytosol and mitochondria. They participate in the control of glycolytic metabolism through interaction with numerous enzymes and play a key r...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-08 | PXD064110 | Pride
High-resolution mass spectrometry  intra- and intermolecular disulfide bonds  rattus voltage-dependent anion selective channel isoform 3 (rvdac3)  cysteine redox state  structural characterization 
UnknownReplacement of the Disulfide Bridge in a KLK3-Stimulating Peptide Using Orthogonally Protected Building Blocks.
Not available
S-EPMC4027621 | biostudies-literature
UnknownFast and Accurate Disulfide Bridge Detection.
Not available
S-EPMC11067345 | biostudies-literature
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