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TranscriptomicsmicroRNA profile of DLBCL
This SuperSeries is composed of the following subset Series: GSE15142: Copy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-21 GSE15177: Copy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microR...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15225 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptional Analysis of Canine and Human Diffuse Large B cell Lymphoma (DLBCL). Molecular Signatures of NF-?B Pathway Activation and Sub-Classification of Canine DLBCL.
In this study, we present the first comparison of global transcriptional changes taking place in canine lymphoma and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappaB (NF-?B) pathway. Microarray data generated from lymph nodes diagnosed with canine D...
ORGANISM(S): Canis lupus familiaris 
2013-09-26 | E-GEOD-30881 | biostudies-arrayexpress
TranscriptomicsTargeting the MTOR-AKT pathway in DLBCL
The mTOR (mammalian Target of Rapamycin) pathway is constitutively activated in Diffuse Large B-Cell Lymphoma (DLBCL). mTOR inhibition has been shown to have clinical activity in patients with DLBCL, although overall response rates remain low. We therefore evaluated differences in the transcriptome...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-27255 | biostudies-arrayexpress
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-77
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas ge...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15177 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes of DLBCL have distinct chromosomal aberrations
We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and ...
ORGANISM(S): Homo sapiens 
2008-09-04 | E-GEOD-11318 | biostudies-arrayexpress
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-21
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas gen...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15142 | biostudies-arrayexpress
Proteomics113 DLBCL SWATH maps by PCT-SWATH
Rapid proteotyping of 41 FFPE DLBCL tumor tissues with 2-3 biological replicates using pressure-cycling technology (PCT) and SWATH mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-07 | PXD014943 | Pride
Pct-dia Swath Ffpe Dlbcl 
TranscriptomicsWhole-transcript expression data from normal and DLBCL human peripheral blood samples
Gene expression profiling based classification of DLBCL patients versus healthy donors provides insights on transcriptional regulation processes. Within the most represented pathways in DLBCL, we identified an innate immune response signature, as well as an anti-inflammatory response. On the other h...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-83632 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in primary Diffuse Large B cell Lymphoma (DLBCL) and normal Germinal Center B Cells
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma with variable biology and clinical behavior. The current classification does not fully explain the biological and clinical heterogeneity of DLBCLs. In this study we carried out genome-wide DNA methylatio...
ORGANISM(S): Homo sapiens 
2014-01-18 | E-GEOD-54200 | biostudies-arrayexpress
TranscriptomicsRetroviral overexpression or siRNA mediated knockdown of FOXP1 in DLBCL cell lines and primary human B cells
To provide insight into the role of and target genes of the transcription factor FOXP1 in mature human B cells and in B cell non-Hodkgin lymhomas, we performed gene expression microarray studies, upon ectopic overexpression or silencing of FOXP1 in these cells. human memory B cells from 2 separate d...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-51382 | biostudies-arrayexpress
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