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UnknownMolecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus.
Not available
S-EPMC3510028 | biostudies-literature
ProteomicsIntegrative cell type-specific multi-omics approaches reveal impaired programs of glial cell differentiation in mouse culture models of DM1
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that interferes with the RNA processing of target genes in multiple tissues. Despite debilitating neurological impairment, the pathophysio...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD025011 | Pride
Myotonic dystrophy Astrocytes Ontology Neurons Multi-omics Splicing Transcriptomics Phosphoproteomics Oligodendrocytes Lc-ms/ms 
UnknownElectrophysiological basis of cardiac arrhythmia in a mouse model of myotonic dystrophy type 1.
Not available
S-EPMC10551179 | biostudies-literature
UnknownDM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus.
Not available
S-EPMC8775431 | biostudies-literature
UnknownIntegrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.
Not available
S-EPMC8136287 | biostudies-literature
TranscriptomicsTherapeutic targeting of the GSK3b-CUGBP1 pathway in Myotonic Dystrophy
Myotonic Dystrophy type 1 (DM1) is a neuromuscular disease associated with toxic RNA containing expanded CUG repeats. Treating mice with the GSK3 inhibitor tideglusib corrected expression of 17% of DM1-related genes. correction of the GSK3β-CUGBP1 pathway in mice expressing long CUG repeats (DMSXL m...
ORGANISM(S): Mus musculus 
2025-07-22 | GSE230821 | GEO
UnknownExcessive rest time during active phase is reliably detected in a mouse model of myotonic dystrophy type 1 using home cage monitoring.
Not available
S-EPMC10017452 | biostudies-literature
GenomicsMus musculus
Mus musculus Raw sequence reads
PRJNA1182323 | ENA
GenomicsDeregulation of alternative splicing by toxic CUG repeats in astrocytes from a mouse model of myotonic dystrophy
Deregulation of alternative splicing by toxic CUG repeats in astrocytes from a mouse model of myotonic dystrophy
PRJNA680559 | ENA
UnknownTargeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice.
Not available
S-EPMC5453865 | biostudies-literature
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