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Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_targeted metabolites

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-16 | MTBLS12731 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
TranscriptomicsTranscriptional analysis of three quorum sensing signals add in experiment inYersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of quorum sensing was investigated by comparing transcript profiles when three quorum-sensing signals are added in. The strai...
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-22846 | biostudies-arrayexpress
TranscriptomicsQuorum sensing and silencing in Vibrio parahaemolyticus
The quorum regulatory cascade is poorly characterized in Vibrio parahaemolyticus, in part because swarming and pathogenicity - the hallmark traits of the organism - are repressed by this scheme of gene control. As a consequence, many isolates appear silenced for quorum sensing via phase variation. I...
ORGANISM(S): Vibrio parahaemolyticus 
2011-12-01 | E-GEOD-28216 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of quorum sensing deficient in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of quorum sensing was investigated by comparing transcript profiles when three quorum-sensing synthase genes are knocked out....
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-21911 | biostudies-arrayexpress
TranscriptomicsTranscription analysis of AI-2 signal add in experiment in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of autoinducer-2 (AI-2) quorum sensing was investigated by comparing transcript profiles when AI-2 quorum-sensing signal is a...
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-22848 | biostudies-arrayexpress
ProteomicsIdentification of DNA-damage sensing factors in D.melanogaster
In order to identify protein involved in sensing DNA double strand breaks and recruiting the repair machinry, we performed in vitro assembly of chromatin on small circular and linear DNA templates, respectively. Proteins involved in chromatin assembly and sensing of free DNA ends were isolated and s...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-10-14 | PXD012990 | Pride
Dna double strand break Repair factors Chromatin assembly 
TranscriptomicsA transcriptome study of DSF-mediated quorum sensing in Xanthomonas axonopodis pv. citri
Quorum sensing (QS) in Xanthomonas axonopodis pv. citri, the causal agent of citrus canker, is mediated by a diffusible signal factor (DSF). QS is required for the full virulence of X. axonopodis pv. citri in planta. Mutations in rpfF, rpfC and rpfG, the core genes of QS, decreased the production of...
ORGANISM(S): Xanthomonas axonopodis pv. citri str. 306 
2012-04-26 | E-GEOD-29877 | biostudies-arrayexpress
TranscriptomicsStudy of the quorum sensing regulon of the acidophilic Acidithiobacillus ferrooxidans ATCC23270 with cDNA microarrays
To address the question of how quorum sensing controls biofilm formation in Acidithiobacillus ferrooxidans ATCC23270, the transcriptome of this organism in conditions in which quorum sensing response is stimulated by a synthetic acyl homoserine lactone (AHL) analogue has been studied. Tetrazole 9c w...
ORGANISM(S): Acidithiobacillus ferrooxidans ATCC 23270 
2017-03-15 | E-MTAB-4896 | biostudies-arrayexpress
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