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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
MetabolomicsSerum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...
2025-08-14 | MTBLS6213 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
GenomicsTOVEL01
Bacterioplankton from Lake Tovel: do space and time matter?
PRJEB25090 | ENA
ProteomicsShotgun proteomics on clade II N2O-reducer enrichments
The majority of potent greenhouse gas nitrous oxide (N2O) emissions originate from microbially mediated reactions. The enzyme N2O reductase is the only known biological N2O sink and has evolved in two phylogenetically distinct lineages (clades I and II). Clade II is of particular interest for biotec...
ORGANISM(S): Escherichia coli 
2025-01-18 | PXD047071 | Pride
Microbial proteomics N2o Shotgun proteomics Metaproteomics 
UnknownEarly oxidative shifts in mouse skeletal muscle morphology with high-fat diet consumption do not lead to functional improvements.
Not available
S-EPMC4270228 | biostudies-literature
UnknownFrom eggs to bites: do ovitrap data provide reliable estimates of Aedes albopictus biting females?
Not available
S-EPMC5357344 | biostudies-literature
GenomicWhole Genome Study for De Novo Mutation Rates

Germline mutations are the source of evolution and contribute substantially to many health-related processes. In this study, we use whole genome deep sequencing data from parents-offspring trios to examine the de novo point mutations (DNMs) in the offspring.

We studied correlation between ...

phs001055 | dbGaP
UnknownExploitation of insect vibrational signals reveals a new method of pest management.
Not available
S-EPMC3310055 | biostudies-literature
TranscriptomicsBru-seq nascent RNA sequencing of human and mouse cells: correlation to replication timing and genome instability
Bru-seq nascent RNA sequencing (PubMed ID 23973811) was performed on two primary human fibroblast cell lines, mouse embryonic stem cells, and GM12878 human lymphoblastoid cells. Read data, which include both exon and intron signals, were used to identify transcription unit spans genome-wide, where a...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-55862 | biostudies-arrayexpress
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