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UnknownThe MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells.
Not available
S-EPMC3984311 | biostudies-literature
UnknownThe alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins.
Not available
S-EPMC2778344 | biostudies-literature
TranscriptomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [HCT116 microarray]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73294 | biostudies-arrayexpress
UnknownBcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.
Not available
S-EPMC4322974 | biostudies-literature
UnknownNeutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.
Not available
S-EPMC8420576 | biostudies-literature
UnknownThe CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis.
Not available
S-EPMC7598068 | biostudies-literature
UnknownThe interplay of TARG1 and PARG protects against genomic instability.
Not available
S-EPMC10933786 | biostudies-literature
TranscriptomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [hMSC microarray]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73601 | biostudies-arrayexpress
UnknownMdm4 supports DNA replication in a p53-independent fashion.
Not available
S-EPMC7521021 | biostudies-literature
GenomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [ChIP-Seq]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73293 | biostudies-arrayexpress
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