Dock2 - OmicsDI

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Comparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells

The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...

ORGANISM(S): Mus musculus

2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress

DOCK2 protects against bacterial sepsis by constraining T helper 1 response

PRJNA1266715 | ENA

DOCK2

PRJNA1085253 | ENA

Transcriptomic profiling of naïve and memory phenotype CD8 T cells in Dock2-deficient mice

PRJNA559381 | ENA

DOCK2 protects against bacterial sepsis by constraining T helper 1 response

Sepsis is a systemic host response to infection with life-threatening consequence, which ranks among the top 10 causes of death worldwide. Nevertheless, our understanding of the molecular and cellular impact of sepsis remains rudimentary. Here, we identified dedicator of cytokinesis 2 (DOCK2) is a c...

ORGANISM(S): Mus musculus

2025-05-22 | GSE297913 | GEO

Essential role of Elmo1 in Dock2-dependent lymphocyte migration.

Not available

S-EPMC4127066 | biostudies-literature

DOCK2 Mutation and Recurrent Hemophagocytic Lymphohistiocytosis.

Not available

S-EPMC9962445 | biostudies-literature

Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2.

Not available

S-EPMC9666545 | biostudies-literature

DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection.