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ProteomicsCaspase-8’s non-apoptotic role is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.
Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Programmed cell death is known to drive inflammation, however, its relevance in the pathogenesis of severe COVID-19 is unclear. Using a combination of gene-targeted murine models and transcriptomic approaches we found that...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-20 | PXD057656 | Pride
Sars-cov-2  caspase-8  inflammation  flip  covid-19  cytokines 
UnknownMycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model.
Not available
S-EPMC11095734 | biostudies-literature
UnknownDeliberation decreases the likelihood of expressing dominant responses.
Not available
S-EPMC7870620 | biostudies-literature
UnknownThe role of MKK4 in T-cell development and immunity to viral infections.
Not available
S-EPMC8247422 | biostudies-literature
UnknownVariola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.
Not available
S-EPMC4385930 | biostudies-literature
UnknownSmelling the romantic partner's natural body odor increases psychological and autonomic but not cortisol stress responses.
Not available
S-EPMC12804818 | biostudies-literature
TranscriptomicsNovel primate miRNAs co-evolved with ancient target genes in germinal zone specific expression patterns [RISC trap immunoprecipitation]
Major non primate-primate differences in corticogenesis include the dimensions, precursor lineages and developmental timing of the germinal zones (GZ). microRNAs (miRNAs) of laser dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP a...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-52607 | biostudies-arrayexpress
UnknownCaspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection.
Not available
S-EPMC8629988 | biostudies-literature
UnknownSuccessful identification of predictive profiles for infection utilising systems-level immune analysis: a pilot study in patients with relapsed and refractory multiple myeloma.
Not available
S-EPMC7790592 | biostudies-literature
UnknownChemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.
Not available
S-EPMC5046154 | biostudies-literature
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