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TranscriptomicsChronic TNBS Colitis in the FN14 KO Mouse
To test TWEAK/Fn14 pathway and relative agents in chronic TNBS colitis Chronic colitis was induced by rectal injection of TNBS with ethanol for 6 weeks in WT or FN14 KO BALB/c mice. Colons were harvested for gene profiling.
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-36806 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of colonic epithelial cells from mice starved, subsequently refed with or without antibiotics metronidazol and vancomycin
Oral food intake maintains gastrointestinal cell turnover and impacts the morphology and function of intestinal epithelial cells. However, the underlying mechanism is not fully elucidated, especially in the large intestine. Therefore, we analyzed the colonic epithelial cell turnover in starved and r...
ORGANISM(S): Mus musculus 
2014-08-11 | E-GEOD-40370 | biostudies-arrayexpress
TranscriptomicsPathological activation of canonical nuclear-factor kB by synergy of tumor necrosis factor alpha and TNF-like weak inducer of apoptosis in mouse acute colitis
To test the efficacy of TNFR-Fc and anti-TWEAK mAb treatment alone and in combination Tumor necrosis factor (TNF)-alpha is a major effector in various inflammatory conditions. TNF-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily that promotes inflammatory tissue damage throu...
ORGANISM(S): Mus musculus 
2014-05-30 | E-GEOD-53835 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis in ESET+/+ and ESET-/- thymocytes
Analysis of ESET deficient thymocytes at gene expression level. Each thymocyte developmental stage (preselected DP, postselected DP and CD4SP) was analysed. Total RNA obtained from isolated subpopulations of thymocytes from ESET+/+ and ESET-/- mice were analysed.
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-73951 | biostudies-arrayexpress
TranscriptomicsIonizing radiation in GI tract of Tweak KO mice
TWEAK/Fn14 signaling may regulate the expression of genes involved in epithelial repair and mucosal inflammation. Comparing the gene signatures in WT and TWEAK KO mice will inform the biology of TWEAK/Fn14 pathway in the GI tract. Mice were treated with 3 Gy of ionizing radiation. After 6h and 24h m...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-25029 | biostudies-arrayexpress
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