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TranscriptomicsTranscription profiling of wild type and Foxa2 knock out mouse mature beta cells
The winged helix transcription factor Foxa2 regulates Pdx1 gene expression and fetal endocrine pancreas development. We show here by inducible gene ablation that Foxa2 inactivation in mature beta-cells induces hyperinsulinemic hypoglycemia in Foxa2loxP/loxP, Pdx1-CreERT2 adult mice. Mutant beta-cell...
ORGANISM(S): Mus musculus 
2007-09-22 | E-CBIL-39 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse islet of Langerhans with FoxA1/A2 knock outs
RNAs were extracted from 10 week adult control and FoxA1/A2 Pdx1CreERT2 mice. FoxA1 and FoxA2 are ablated in adult mouse Beta cells by tamoxifen adminstration. We aim to study the roles of FoxA1 and FoxA2 on islet gene expression when they are knocked down.
ORGANISM(S): Mus musculus 
2010-06-23 | E-MTAB-219 | biostudies-arrayexpress
TranscriptomicsPdx1 maintains ?-cell identity and function by repressing an ?-cell program
To get a more complete picture of the transcriptional changes associated with Pdx1 loss in ?-cells, we conducted an mRNA microarray comparing normal islet ?-cells and a-cells to the reprogrammed cells from PKO mice. Islet beta cells are from mice which has a single copy of Pdx1 flox (Pdx1L/+) allele...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-52258 | biostudies-arrayexpress
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