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UnknownIdentification of simple arylfluorosulfates as potent agents against resistant bacteria.
Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure-activity relationship studies of a series of arylfluorosulfates, synthesized via SuFEx, as antibacterial agents. Arylfluorosulfates 3, 81, and 101 sh...
S-EPMC8285976 | biostudies-literature
ProteomicsAdaptiven mechanism of antibiotic resistant Staphylococus aureus to host environment
Antibiotic-resistant bacteria can escape from the killing of host immune and settle in the host to form persistent infections. In this study, we investigated the environmental adaptation mechanism of resistant Staphyloccus aureus (S. aureus) to host environment by Data-independent acquisition based ...
ORGANISM(S): Staphylococcus aureus 
2022-05-31 | PXD029584 | Pride
Host environment Ciprofloxacin-resistant Proteomics Staphylococcus aureus 
UnknownKPT330 improves Cas9 precision genome- and base-editing by selectively regulating mRNA nuclear export.
CRISPR-based genome engineering tools are associated with off-target effects that constitutively active Cas9 protein may instigate. Previous studies have revealed the feasibility of modulating Cas9-based genome- and base-editing tools using protein or small-molecule CRISPR inhibitors. Here we screen...
S-EPMC8931069 | biostudies-literature
UnknownSpecific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although many assays are available, highly robust and reliable methods are always desired. By combining...
S-EPMC10103678 | biostudies-literature
ProteomicsMulti-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury_human data
We conducted a randomized controlled clinical trial investigating the effects of resistance exercise therapy for incomplete SCI. We integrated the analysis of plasma proteomics to explore the molecular and cellular changes induced by resistance exercise.
ORGANISM(S): Homo Sapiens 
2025-01-26 | PXD060193 |
ProteomicsMulti-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury_mouse data
We established a weight-loaded ladder-climbing mouse model to mimic the physiological effects of resistance exercise, and we analyzed the plasma proteome.
ORGANISM(S): Mus Musculus 
2025-01-26 | PXD060217 |
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