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ProteomicsDegron-independent recruitment of KAT2A redefines the breadth of CRBN-based molecular-glue targets
Lysine acetyltransferases (KATs) frequently cooperate with oncogenes such as c-Myc, estrogen receptor, and KMT2A-fusions to sustain malignant programs. Therapeutic targeting of KAT proteins has shown clinical efficacy, yet achieving homolog-selectivity for most KATs remains a major challenge. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD072306 | Pride
Ubiquitin Kat2a Crbn Molecular glue Lysine acetyltransferases Protein degradation E3 ligase Aml 
ProteomicsDegron-independent recruitment of KAT2A redefines the breadth of CRBN-based molecular-glue targets
Lysine acetyltransferases (KATs) frequently cooperate with oncogenes such as c-Myc, estrogen receptor, and KMT2A-fusions to sustain malignant programs. Therapeutic targeting of KAT proteins has shown clinical efficacy, yet achieving homolog-selectivity for most KATs remains a major challenge. Here, ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD072361 | Pride
UnknownBrain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome.
Not available
S-EPMC4309554 | biostudies-literature
TranscriptomicsDNA methylation analysis of melanoma progression to brain metastasis
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44661 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression array data for melanoma progression to the brain
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for metastatic melanoma specimens
Comparison between the copy number of differentially methylated sites between lymph node metastasis from melanoma patients with good prognosis and melanoma brain metastasis. All samples are taken from different patients, and were established as cell lines in the John Wayne Cancer Institute. Sixteen ...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44019 | biostudies-arrayexpress
UnknownEpigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis.
Not available
S-EPMC3857956 | biostudies-literature
UnknownAffymetrix expression array data for melanoma progression to the brain
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-44660 | biostudies-other
UnknownNFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.
Not available
S-EPMC1877820 | biostudies-literature
UnknownEarly biological markers of post-acute sequelae of SARS-CoV-2 infection.
Not available
S-EPMC11358427 | biostudies-literature
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