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TranscriptomicsAn Invasive Gene Expression Signature in Pancreas Cancer
Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Chinese Hamster Ovary production cell lines
The dataset set consists of 295 microarrays from 121 individual CHO cultures producing a range of biologics including monoclonal antibodies, fusion proteins and therapeutic factors; non-producing cell lines were also included. Samples were taken from a wide range of process scales and formats that v...
ORGANISM(S): Cricetulus griseus 
2011-07-27 | E-GEOD-30321 | biostudies-arrayexpress
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Fast vs. Slow Chinese Hamster Ovary cell lines using Wye3aHamster array
A 3rd generation Wye3aHamster microarray chip was used to carry out a differential expression microarray study of a panel of 30 slow- and fast-growing production cell lines, identifying a priority list of 240 transcripts (110 Up; 130 Down) that passed a statisical filter (ANOVA p-value <0.05, 1.3 f...
ORGANISM(S): Cricetulus griseus 
2013-01-01 | E-GEOD-37251 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Gene Expression Analysis
Analysis of 104 breast cancer biopsies (removed prior to any treatment with tamoxifen or chemotherapeutic agents) from patients aged between 31 years and 89 years at the time of diagnosis (mean age = 58 years). Twenty were less than 50 years and seventy-seven women were 50 years, or older, at diagno...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42568 | biostudies-arrayexpress
TranscriptomicsGenome-wide changes in subcutaneous adipose tissue expression in HIV negative adults after 2 weeks of zidovudine or stavudine with lamivudine.
As controversy remains as to the exact mechanisms by which the thymidine-analogue nucleoside reverse transcriptase inhibitors, zidovudine (AZT) and stavudine (d4T) induce subcutaneous adipose tissue toxicity, we used microarrays to dentify patterns of gene expression in human subcutaneous adipose ti...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34302 | biostudies-arrayexpress
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