Sort   by:  
 Page size 
TranscriptomicsDeriving Dopaminergic Neurons for Clinical Use. A Practical Approach.
Identification of new small molecules that regulate the step-wise differentiation of hPSC into dopaminergic neurons population. Furthermore, the naturally occurring steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. Total RNA extracted...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-42265 | biostudies-arrayexpress
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ of Satb1-knockdown in dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse dopaminergic neurons from the mouse mid-brain, with AAV1 injections using a Satb1 shRNA-EGFP construct or a scrambed shRNA-EGFP construct Murine midbrain dopaminergic neurons with Satb1 shRNA treatment or scrambled control
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-70133 | biostudies-arrayexpress
TranscriptomicsUnexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
The mesencephalic dopaminergic (mDA) cell system is composed by two major groups of projecting cells in the Substantia Nigra (A9 neurons) and the Ventral Tegmental Area (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Th...
ORGANISM(S): Mus musculus 
2010-02-25 | E-GEOD-16192 | biostudies-arrayexpress
TranscriptomicsKC002-EH005: Genetic and epigenetic features of induced pluripotent stem cell-derived dopaminergic neurons
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro disease modeling and cell replacement therapy for Parkinson’s disease (PD). Both applications crucially require an in-depth profiling of the disease-relevant, iPSC-derived cell type. Midbrain dopaminergic (mDA) neurons derived fr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47178 | biostudies-arrayexpress
GenomicsChIP-Seq for Pbx1 in the mouse E12.5 ventral midbrain
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease One sample each for Pbx1, IgG, and input
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82098 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mouse E12.5 brain regions
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease Three samples each from dorsal midbrain, forebrain, hindbrain, Alar plate, and ventral midbrain
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82099 | biostudies-arrayexpress
TranscriptomicsThe divergent nodes of non-autonomous UPRER signaling through serotonergic and dopaminergic neurons
Performed RNA-seq analysis of animals with xbp-1s overexpression (ER stress response transcription factor) in specific neuron types: pan-neuronal, serotonergic neuron, dopaminergic neuron, and both serotonergic and dopaminergic neurons, all compared to a wild-type control. RNA-seq was performed on p...
ORGANISM(S): Caenorhabditis elegans 
2021-01-01 | E-MTAB-9771 | biostudies-arrayexpress
TranscriptomicsChIP-seq of SATB1-bound regions in human ESC-derived dopaminergic (DA) neurons at different time points. ATAC-Seq and RNA-Seq of DA and cortical neurons (WT and SATB1-KO)
SATB1 is a genetic master regulator in dopaminergic neurons. We try to identify the downstream regulated genes and pathways of SATB1 in human dopaminergic and CTX neurons. The RNA-Seq experiment was performed to investigate the role of the genetic master regulator SATB1 in human dopaminergic neurons...
ORGANISM(S): Homo sapiens 
2019-09-20 | E-MTAB-5965 | biostudies-arrayexpress
TranscriptomicsStromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
The identified stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. Human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons are potentially useful for treating Parkinson’s disease (PD) through cell replacement therapy. Gen...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-20503 | biostudies-arrayexpress
Sort   by:  
 Page size