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TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (tiling)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42360 | biostudies-arrayexpress
TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (sequencing)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42397 | biostudies-arrayexpress
TranscriptomicsCohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes [expression array data]
Cohesin is crucial for proper chromosome segregation, but also regulates gene transcription and organism development by poorly understood mechanisms. We find that in Drosophila, cohesin functionally interacts with Polycomb group (PcG) silencing proteins at both silenced and active genes. Cohesin une...
ORGANISM(S): Drosophila melanogaster 
2013-04-25 | E-GEOD-42105 | biostudies-arrayexpress
TranscriptomicsHairpin Capture of DNA End Structures reveals chromosomal DNA end structure with single nucleotide resolution
The structure of broken DNA ends is a critical determinant of the pathway used for DNA double strand break (DSB) repair. Here, we develop an approach, hairpin capture of DNA end structures (HCoDES), which elucidates chromosomal DNA end structures at single nucleotide resolution. HCoDES defines str...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62534 | biostudies-arrayexpress
TranscriptomicsCohesin and Polycomb proteins functionally interact to control transcription at silenced, restrained, and active genes [tiling array data]
Cohesin is crucial for proper chromosome segregation, but also regulates gene transcription and organism development by poorly understood mechanisms. We find that in Drosophila, cohesin functionally interacts with Polycomb group (PcG) silencing proteins at both silenced and active genes. Cohesin une...
ORGANISM(S): Drosophila melanogaster 
2013-04-25 | E-GEOD-42104 | biostudies-arrayexpress
TranscriptomicsUbiquitinated histone H2A mapping in Drosophila ML-DmBG3 cells
Monoubiquitinated histone H2A produced by the Sce/Ring subunit of the Polycomb Repressive Complex 1 (PRC1) was mapped genome-wide in Drosophila ML-DmBG3 cells using chromatin immunoprecipitation followed by hybridization to Affymetrix tiling arrays. ML-DmBG3 chromatin immunoprecipitated with anti-h...
ORGANISM(S): Drosophila melanogaster 
2013-08-09 | E-GEOD-49634 | biostudies-arrayexpress
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