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UnknownThe integrated endoplasmic reticulum stress response in Leishmania amazonensis macrophage infection: the role of X-box binding protein 1 transcription factor.
Endoplasmic reticulum (ER) stress triggers the integrated ER-stress response (IERSR) that ensures cellular survival of ER stress and represents a primordial form of innate immunity. We investigated the role of IERSR duringLeishmania amazonensisinfection. Treatment of RAW 264.7 infected macrophages w...
S-EPMC7163978 | biostudies-literature
UnknownTRANSFUSAO DE PLASMA CONVALESCENTE EM COVID19: ASSOCIACAO ENTRE ANTICORPOS NEUTRALIZANTES E REDUCAO DE CARGA VIRAL

Introdução

A transfusão de plasma convalescente tem sido utilizada como terapêutica alternativa no tratamento de COVID19 nos últimos meses. Avaliamos o impacto dos anticorpos neutralizantes produzidos pelos pacientes e dos anticorpos presentes nas unidades transfundidas na redução da carga ...
S-EPMC8530592 | biostudies-literature
UnknownData on roasted coffee with specific defects analyzed by infrared-photoacoustic spectroscopy and chemometrics.
This article contains data related to the research article entitled "Quantitative assessment of specific defects in roasted ground coffee via infrared-photoacoustic spectroscopy" (Dias et al., 2018) [1]. A method potentially able for assessing the quality of roasted ground coffees is described in th...
S-EPMC6104563 | biostudies-literature
UnknownImpact of protein prenylation inhibition on <i>Mycobacterium leprae</i> viability and IL-1β production in infected macrophages.
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M. leprae upregulates the mevalonate pathway (MP), contributing to ...
S-EPMC12445085 | biostudies-literature
UnknownAdenosine A2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage.

Background

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which can lead to a disabling neurodegenerative condition. M. leprae preferentially infects skin macrophages and Schwann cells-glial cells of the peripheral nervous system. The infection modifies...
S-EPMC11239521 | biostudies-literature
UnknownComposite Based on Biphasic Calcium Phosphate (HA/β-TCP) and Nanocellulose from the Acai Tegument.
The use of lignocellulosic remnants of the açaí agro-business will benefit the environment with a precursor material for biomedical applications. Nanocellulose (NC) allows the biomimetic growth of biphasic ceramics on its surface, with characteristics compatible with bone tissue, including bioactive...
S-EPMC6266682 | biostudies-literature
UnknownExploring Novel 2D Analogues of Goldene: Electronic, Mechanical, and Optical Properties of Silverene and Copperene.
Two-dimensional (2D) materials have garnered significant attention due to their unique properties and broad application potential. Building on the success of goldene, a monolayer lattice of gold atoms, we explore its proposed silver and copper analogues, silverene and copperene, using density functi...
S-EPMC12223819 | biostudies-literature
UnknownMorinda citrifolia Essential Oil: A Plant Resistance Biostimulant and a Sustainable Alternative for Controlling Phytopathogens and Insect Pests.
With the growing demand for sustainable and safe agricultural practices, plant compounds emerge as a solution for biological activities. Here, we evaluated the potential of using Morinda citrifolia essential oil to induce plant resistance and to control phytopathogens (Curvularia lunata
S-EPMC11274064 | biostudies-literature
UnknownINTERLINK-1: A Phase III, Randomized, Placebo-Controlled Study of Monalizumab plus Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma.

Purpose

Treatment options for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) after failure of immune checkpoint inhibitor treatment and platinum-based chemotherapy are limited. Preliminary data suggested that monalizumab plus cetuximab had clinical activity in R/M H...
S-EPMC12209814 | biostudies-literature
UnknownBarbituric Acid Derivatives as Covalent Inhibitors of <i>Leishmania braziliensis</i> Dihydroorotate Dehydrogenase.
Covalent drug design applied to parasite proteins enables selective therapies by targeting nucleophilic residues of macromolecules. We present the first covalent inhibitors of Leishmania braziliensis dihydroorotate dehydrogenase (LbDHODH), a key enzyme in pyrimidine biosynthesis...
S-EPMC12481576 | biostudies-literature
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