Sort   by:  
 Page size 
TranscriptomicsThe transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Here we tracked transcriptome changes over ten human hematopoietic stem and early progenitor populations, defining the transcriptional dynamics underlying the first steps of commitment. Most of the transcriptional programs observed extended beyond lineage boundaries. In particular, multi-lymphoid pr...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42414 | biostudies-arrayexpress
TranscriptomicsIsolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
Gene expression profiling was used to investigate the relationship between human cord blood hematopoietic stem cells (HSC) and multipotent progenitors described in the study. Genes more highly expressed in HSC may be associated with stem cell function and self-renewal. Total RNA was obtained from fl...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-29105 | biostudies-arrayexpress
TranscriptomicsRe-specification of myeloid precursors from human pluripotent cells into engraftable multi-lineage progenitors
Human pluripotent stem cells were differentiated into hematopoietic progenitors, which were then re-specified using defined transcription factors to resemble hematopoietic stem cells (HSC) We used microarrays to establish the similarity between converted cells and purified human HSCs. The samples an...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-49938 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
Sort   by:  
 Page size