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TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
UnknownA C4 plant K+ channel accelerates stomata to enhance C3 photosynthesis and water use efficiency.
Not available
S-EPMC11837344 | biostudies-literature
UnknownABA activates multiple Ca(2+) fluxes in stomatal guard cells, triggering vacuolar K(+)(Rb(+)) release.
Not available
S-EPMC17347 | biostudies-literature
UnknownDefective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Not available
S-EPMC3682340 | biostudies-literature
GenomicsDNA methylation of Rhabdomyosarcoma tumors
DNA methylation data from patient RMS tumor samples from Illumina 450 K arays
EGAD00010001596 | EGA
UnknownAn unusually rich scuttle fly fauna (Diptera, Phoridae) from north of the Arctic Circle in the Kola Peninsula, N. W. Russia.
Not available
S-EPMC3817429 | biostudies-literature
UnknownFast and accurate relatedness estimation from high-throughput sequencing data in the presence of inbreeding.
Not available
S-EPMC6488770 | biostudies-literature
UnknownDecoding a highly mixed Kazakh genome.
Not available
S-EPMC7170836 | biostudies-literature
UnknownGlobal genetic positioning: evidence for early human population centers in coastal habitats.
Not available
S-EPMC1334655 | biostudies-literature
TranscriptomicsWild-Type Nras Lacks Tumor Suppressor Activity and Nras Oncogene Dosage Strongly Modulates Hematopoietic Transformation
Contemporary treatment of pediatric acute myeloid leukemia (AML) requires the assignment of patients to specific risk groups. To explore whether expression profiling of leukemic blasts could accurately distinguish between the known risk groups of AML, we analyzed 130 pediatric and 20 adult AML diagn...
ORGANISM(S): Homo sapiens 
2013-07-02 | E-GEOD-43176 | biostudies-arrayexpress
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