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TranscriptomicsExpression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls
In order to characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we compared gene expression in uncultured amniotic fluid supernatant samples. We identified individually differentially expressed genes via paired t-tests in the matched samples, and a set of di...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-16176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21
Detection of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21.
ORGANISM(S): Mus musculus 
2005-11-19 | E-MEXP-409 | biostudies-arrayexpress
TranscriptomicsAmniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome
Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Tu...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-GEOD-58435 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome
Down syndrome is characterized by a complex phenotype that includes developmental disabilities and congenital anomalies. The molecular origin of these abnormalities is poorly understood. The objective of this study is to analyze whole transcriptome changes in the cortex and hippocampus of the Ts1Cje...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-49635 | biostudies-arrayexpress
ProteomicsHRMS1 DIA and DDA of Lyso-IP inputs from mouse gut epithelium and stem cells
These mouse gut lysates contained three sets, with Set A including 21 DDA experiments and 21 DIA experiments, Set C including 24 DDA and 24 DIA experiments, and Set G including 27 DDA RAWs and 26 DIA RAWs (one of the Set G DDA experiments was run twice). Experiment Set A was intended to compare lys...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-07-26 | MSV000095444 | MassIVE
TranscriptomicsDksA Guards Elongating RNA Polymerase Against Ribosome-Stalling-Induced Arrest
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independent...
ORGANISM(S): Escherichia coli 
2014-04-21 | E-GEOD-54669 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Fetal and Neonatal Transcriptomic and Neurocognitive Phenotype in the Ts1Cje Mouse Model of Down syndrome
Down syndrome is characterized by a complex phenotype that includes developmental disabilities and congenital anomalies emerging during fetal life. The molecular origin of these abnormalities is poorly understood. Despite the evidence of prenatal onset of the phenotype, most therapeutic trials have ...
ORGANISM(S): Mus musculus 
2014-11-15 | E-GEOD-62538 | biostudies-arrayexpress
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