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TranscriptomicsExpression data from Ts1Cje and disomic C57BL/6 adult neurospheres
Down syndrome is the most common form of genetic mental retardation. How Trisomy 21 causes mental retardation remains unclear and its effects on adult neurogenesis have not been addressed. To gain insight into the mechanisms causing mental retardation we used microarrays to investigate gene expressi...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-17760 | biostudies-arrayexpress
TranscriptomicsDistinct DNA methylation patterns of cognitive impairment and Trisomy 21 in Down Syndrome
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer’s Disease (AD). While the mechanism underlying these changes is unknown, it has been hy...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50586 | biostudies-arrayexpress
GenomicsA comparison of control samples for ChIP-seq of histone modifications
The advent of high-throughput sequencing has allowed genome wide profiling of histone modifications by Chromatin ImmunoPrecipitation (ChIP) followed by sequencing (ChIP-seq). In this assay the histone mark of interest is enriched through a chromatin pull-down assay using an antibody for the mark. Du...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-59419 | biostudies-arrayexpress
TranscriptomicsExpression data for inbred mouse brains
Prion diseases are fatal neurodegenerative disorders that include bovine spongiform encephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans. They are characterized by long incubation periods, variation in which is determined by many factors including genetic backgro...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-38205 | biostudies-arrayexpress
UnknownTropical Data: Approach and Methodology as Applied to Trachoma Prevalence Surveys.
Not available
S-EPMC10751062 | biostudies-literature
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
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