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TranscriptomicsGene expression profile of FOXM1 with Doxorubicin in MDA-MB-231 breast cancer cells
Transcription factors (TFs) play a crucial role in diverse cellular physiology by controlling down-stream target genes. It has been well recognized that TFs are attractive target for treating human cancer since transcriptional activity or gene expression level of TFs can be directly modulated. To ex...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-25741 | biostudies-arrayexpress
TranscriptomicsTargeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment
Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3 alleles in ErbB3FL/FL were cultured in the presence or absence of doxycycline to induce ErbB3 loss. The gene expression shift following DOX-induce...
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-32129 | biostudies-arrayexpress
Transcriptomicsmurine MYC-dependent lymphoma cells: Dox vs. NoDox treatment
miRNA expression profiling of murine MYC-dependent lymphoma cell lines harboring the MYC-transgene in a Tet-off system comparing control untreated lymphoma cells (high MYC expression state) with 18hours Dox treated lymphoma cells (low MYC expression state). Keywords: inducible expression system Two...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12394 | biostudies-arrayexpress
TranscriptomicsExpression data throughout reprogramming of MEF to iPS using a Dox-inducible promoter
6C secondary MEFs were treated with Dox in mES media to turn on the Oct4, Klf4, cMyc, Sox2. Total RNA was extracted at day 0 (no Dox), day2, 5, 8, 11, 16 and 21 (with Dox) and day 30 (Dox-independent secondary iPS). RNA from Parental MEFs and Primary-iPS cells were also extracted for reference. 1B s...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21757 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of PST-Dox nanoparticles on isolated normal lymphocytes and in cancer cell lines
Analysis of expression variation of PST-Dox nanoaprticles for elucidating the molecular mechanism of action in cancer cell lines and normal lymphocytes. Total RNA isolated from PST-Dox treated cells subjected to 24 hr treatment compared to untreated samples.
ORGANISM(S): Homo sapiens 
2014-05-02 | E-GEOD-46570 | biostudies-arrayexpress
TranscriptomicsHuman Dox+ vs Dox-
01-A03_p65.sample This GEO Series was created by the GEO staff as part of a cleanup effort to ensure that all GEO Samples are included within a Series entry.
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-25758 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of withdrawal of miR-155 hyperexpression in miR-155-addicted tumors
Overexpression of miR-155 in hematological tissue leads to the onset of lymphoma, and Tet-off shutdown of this overexpression reverses the disease phenotype in mir-155LSLtTA mice. This study compares the gene expression profiles of tumors with miR-155 overexpression and withdrawal. Examination of mR...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61851 | biostudies-arrayexpress
TranscriptomicsDifferentiating i-Mixl1 mESCs cultured in the presence or absence of Doxycycline
We profiled gene expression changes in differentiating i-Mixl1 ES cells(Willey, Ayuso-Sacido et al., 2006, Blood 107(8): 3122-3130) cultured in the presence or absence of Doxycycline (DOX, 0.1 ug/ml, 3 replicates per treatment/time point). Total RNA was isolated from EBs harvested at day 2, 3 and ...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-40703 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profile of the Tet-On HCT116 inducible cell line that express either the human HNF4α2 or HNF4α8 under control of Doxycycline (DOX) [RNAseq]
Purpose: Aim of the study is to identify functional differences between the P1 and P2-HNF4α isoforms. To do this, we generated Tet-On inducible lines that express either the human (P1) HNF4α2 or (P2) HNF4α8 under control of DOX in the HCT116 human colon cancer cells. Methods: HNF4α2 and Parental lin...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-62889 | biostudies-arrayexpress
TranscriptomicsA Genome-wide Transcriptional Analysis of Morphology Determination in Candida albicans
Candida albicans, the most common cause of human fungal infections, undergoes a reversible morphological transition from yeast to pseudohyphal and hyphal filaments, which is required for virulence. For many years, the relationship between global gene expression patterns associated with determination...
ORGANISM(S): Candida albicans 
2012-12-12 | E-GEOD-39677 | biostudies-arrayexpress
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