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TranscriptomicsExpression data in human renal cell carcinoma samples from patients who did or did not respond to anti-PD-1 (Nivolumab) immunotherapy
Pre-treatment tumor expression of PD-L1 has been shown to correlate with favorable clinical outcomes following PD-1 blocking therapies. However, the majority of patients with PD-L1+ tumors do not respond to treatment. With the goal of obtaining insights into the mechanisms underlying the response to...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-67501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4 T Cells reveals Tumor and Self-Recognition Induce Distinct Transcriptional Profiles in Antigen-Specific CD4 T cells
Tumors express a wide variety of both mutated and non-mutated antigens. Whether these tumor antigens are broadly recognized as “self” or “foreign” by the immune system is currently unclear. Using an autochthonous prostate cancer model in which hemagglutinin (HA) is specifically expressed in ...
ORGANISM(S): Mus musculus 
2009-02-08 | E-GEOD-14662 | biostudies-arrayexpress
UnknownSurvival, Durable Response, and Long-Term Safety in Patients With Previously Treated Advanced Renal Cell Carcinoma Receiving Nivolumab.
Not available
S-EPMC4517051 | biostudies-literature
TranscriptomicsTranscription profiling of mouse naive CD4+CD25-CD62Lhi T cells and nTreg cells with Eos knock-down
Eos expression in Treg cells have been documented by several microarrays including ours. We hypothesized that Eos facilitates Foxp3- dependent gene repression in Regulatory T cells. In order to investigate the role of Eos in mediating the Foxp3-dependent gene silencing program, we utilized lentivir...
ORGANISM(S): Mus musculus 
2009-10-16 | E-GEOD-17166 | biostudies-arrayexpress
UnknownNull alleles are ubiquitous at microsatellite loci in the Wedge Clam (Donax trunculus).
Not available
S-EPMC5398275 | biostudies-literature
UnknownImplications for management and conservation of the population genetic structure of the wedge clam Donax trunculus across two biogeographic boundaries.
Not available
S-EPMC5171699 | biostudies-literature
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
TranscriptomicsBlood mRNA expression signatures derived from unsupervised analyses identify prostate cancers with poor outcome
Background: Inter-patient prostate cancer (PrCa) heterogeneity results in highly variable patient outcomes. Multi-purpose biomarkers to dissect this heterogeneity are urgently required to improve treatment and accelerate drug development in PrCa. Circulating biomarkers are most practical for evaluat...
ORGANISM(S): Homo sapiens 
2012-10-15 | E-GEOD-37199 | biostudies-arrayexpress
TranscriptomicsObesity study in transgenic and knockout animals
A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our m...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-12000 | biostudies-arrayexpress
TranscriptomicsGas7 male transgenic liver expression vs FVB male wildtype control
A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our m...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11996 | biostudies-arrayexpress
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