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TranscriptomicsMultiple insert size paired-end sequencing for deconvolution of complex transcriptomes
Deep sequencing of transcriptomes allows quantitative and qualitative analysis of many RNA species in a sample, with parallel comparison of expression levels, splicing variants, natural antisense transcripts, RNA editing and transcriptional start and stop sites the ideal goal. By computational model...
ORGANISM(S): Caenorhabditis elegans 
2012-08-31 | E-GEOD-40507 | biostudies-arrayexpress
TranscriptomicsRNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promo...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56887 | biostudies-arrayexpress
TranscriptomicsDetermination and Inference of Eukaryotic Transcription Factor Sequence Specificity
The DNA sequence preferences of the vast majority of eukaryotic transcription factors (TFs) are unknown. Using an approach designed to broadly sample both DNA-binding domain types and eukaryotic clades, we have determined DNA-binding motifs for 1,033 TFs from 131 diverse eukaryotes, encompassing 54...
ORGANISM(S): synthetic construct 
2014-08-01 | E-GEOD-53348 | biostudies-arrayexpress
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