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MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
MetabolomicsImpaired Glycolysis-Derived Serine Metabolism as a Key Driver of Podocyte Injury with Senescence

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kina...

2025-08-23 | MTBLS12883 | MetaboLights
TranscriptomicsFrequent driver mutations in histone H3.3 and chromatin remodeling genes in paediatric glioblastoma
Whole exome sequencing identified frequent driver mutations in a series of paediatric glioblastomas We used microarray-based profiling to investigate differences in gene expression according to mutational status of driver genes RNA from 27 primary tumor samples was subject to QC by Agilent BioAnalys...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-34824 | biostudies-arrayexpress
ProteomicsIntegrative omics reveals magnesium deficiency as a driver factor of colorectal cancer
Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), but the underlying mechanisms remain elusive. In our study, we used genomic, proteomic, and phosphoproteomic data to reveal the effects of low Mg content on genomic instability and tumor metastasis...
ORGANISM(S): Homo Sapiens 
2023-06-05 | PXD042746 |
TranscriptomicsExpression from hemocytes misexpressing Idh-R195H vs. controls
Expression profile for hemocytes from hml-Gal4, UAS-2xEGFP larvae were compared to hemocytes from hml-Gal4, UAS-2xEGFP; UAS-Idh-R195H larvae We sought to determine which genes and pathways were upregulated or downregulated in hemocytes expressing Idh-R195H, the Drosophila homolog of the human cancer...
ORGANISM(S): Drosophila melanogaster 
2014-10-03 | E-GEOD-62008 | biostudies-arrayexpress
ProteomicsEvolution of the reproductive interactome and the origins of postmating–prezygotic reproductive divergence
Reproductive proteins evolve rapidly, which is predicted to cause postmating-prezygotic (PMPZ) reproductive isolation between divergent populations. While most previous studies have focused on protein sequence divergence as a likely driver of PMPZ incompatibilities, reproductive proteomes may also d...
ORGANISM(S): Drosophila mojavensis mojavensis Drosophila arizonae 
2026-04-02 | PXD065290 | Pride
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
TranscriptomicsGene expression changes in Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4 [RNA-seq]
We specifically deleted Mettl14 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl14 function in mouse uterus, uterine tissues were collected from Mettl14f/f and Mettl14d/d mice on gestational day 4 and subjected to RNA-seq analysis.
ORGANISM(S): Mus musculus 
2024-04-12 | GSE263378 | GEO
TranscriptomicsSingle-cell RNA-seq analysis of Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4
We specifically deleted Mettl14 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl14 function in mouse uterus, uterine tissues were collected from Mettl14f/f and Mettl14d/d mice on gestational day 4 and subjected to single-cell RNA-seq analysis.
ORGANISM(S): Mus musculus 
2024-04-25 | GSE264490 | GEO
GenomicsGene expression changes in Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4 [RNA-seq]
Gene expression changes in Mettl14d/d mouse uterus compared to Mettl14f/f mouse uterus on gestational day 4 [RNA-seq]
PRJNA1096999 | ENA
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