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TranscriptomicsExpression in Aneuploid Drosophila S2 Cells
Chromosomal and segmental aneuploidies are usually lethal or common features of cancer cells and variety of disease, but little is known about how copy number relates to gene expression. Drosophila males have a single X chromosome and two sets of autosomes, but X chromosome and autosome transcripts ...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-16344 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of Drosophila Schneider S2 cells treated with dsRNA vs. GFP
Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals that endogenous sma...
ORGANISM(S): Drosophila melanogaster 
2008-06-20 | E-GEOD-11370 | biostudies-arrayexpress
ProteomicsCharacterization of the redox proteome of Drosophila melanogaster S2 cells and w1118 fly eyes.
Reactive oxygen species (ROS) serve as intracellular signaling molecules; however, in excess ROS molecules are damaging to biomacromolecules such as DNA, lipids, and proteins. The excess accumulation of ROS leads to oxidative stress, disrupting redox homeostasis in the cell and has been linked with ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-04-27 | PXD034050 | Pride
Drosophila melanogaster schneider s2 cells Drosophila eye Redox proteome Blue light 
ProteomicsDrosophila Schneider S2 cell TFIIA-L Immunoprecipitation
In order to identify interaction partner of the Drosophila melanogaster TFIIA protein, we have immunoprecipitated an endogenously 3xFLAG-AID tagged TFIIA-L from Drosophila Schneider S2 cells
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-16 | PXD028094 | Pride
Tfiia Drosophila Ip-ms 
TranscriptomicsTiling path analysis of Drosophila Schneider 2 cultured cells to map forum domains
Forum domains are stretches of chromosomal DNA that are excised from eukaryotic chromosomes during their spontaneous non-random fragmentation. Mostly forum domains are of 50-200 kb in length, although larger domains, up to 500 - 700 kb, are also observed.

We performed a genome-wide mapping o...
ORGANISM(S): Drosophila melanogaster 
2010-11-01 | E-MEXP-2468 | biostudies-arrayexpress
GenomicsChIPseq analysis of MYST5 (cg1894) in Drosophila S2 cells
We report here the genome-wide localization of the histone acetyltransferase MYST5 (cg1984) in Drosophila. ChIP-seq analysis was performed with two anti-MYST5 antibodies in S2 cells. We found MYST5 to bind to the promoters of actively transcribed genes. MYST5 furthermore showed extensive colocalizat...
ORGANISM(S): Drosophila melanogaster 
2016-02-23 | E-GEOD-66212 | biostudies-arrayexpress
TranscriptomicsRNA-Seq on libraries made from ERCC external RNA controls, and a mixture of D. melanogaster S2 cell mRNA and ERCC mRNAs
RNA-Seq on libraries made from External RNA Controls Consortium (ERCC) external RNA controls, and a mixture of mRNA from Drosophila melanogaster S2 cell and ERCC mRNAs. We evaluated performance of RNA-Seq on known synthetic PolyA+ mRNAs from the External RNA Controls Consortium (ERCC) alone and in ...
ORGANISM(S): synthetic construct 
2010-04-19 | E-GEOD-20579 | biostudies-arrayexpress
TranscriptomicsMLE HITS-CLIP in Drosophila S2 cells
HITS-CLIP was carried out on wild-type Schneider (S2) cells using specific MLE antibodies to identify binding sites for MLE in the Drosophila transcriptome
ORGANISM(S): Drosophila melanogaster 
2013-10-30 | E-MTAB-1706 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of mRNA decapping co-activators in Drosophila S2 cells
We analyzed mRNA expression profiles in Drosophila melanogaster S2 cells that had been depleted of proteins known as mRNA decapping co-activators. mRNA decapping is catalyzed by DCP2, and DCP2 activity is stimulated by decapping co-activators. This group of proteins includes DCP1, Hedls (also known ...
ORGANISM(S): Drosophila melanogaster 
2007-09-03 | E-MEXP-1012 | biostudies-arrayexpress
TranscriptomicsX chromosome dosage compensation via enhanced transcriptional elongation in Drosophila males (Untreated)
MSL (Male-specific lethal) complex increases transcription on the single X chromosome of Drosophila males in order to equalize expression of X-linked genes between males (XY) and females (XX). The increase in transcript levels correlates with MSL- dependent acetylation of histone H4 at K16 within th...
ORGANISM(S): Drosophila melanogaster 
2010-12-22 | E-GEOD-25321 | biostudies-arrayexpress
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