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GenomicsBRD7 is a candidate tumour suppressor gene required for p53 function
Oncogene-induced senescence (OIS) is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations while others show a dysfunctional p53 pathway, frequently by unknown mechanisms. We identified BRD7, a bromodomain-containing protein whos...
ORGANISM(S): Homo sapiens 
2010-03-14 | E-GEOD-20076 | biostudies-arrayexpress
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
UnknownMesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
Not available
S-SCDT-EMM-2022-16001 | biostudies-other
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