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TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsComparison of aCGH profiles from KB1C61GP, KB1P and KP mouse mammary tumors
While BRCA-related cancers respond well to double-strand break (DSB) inducing agents, resistance is a serious clinical problem. One mechanism of resistance is reversion of the BRCA1 mutation, suggesting that BRCA1 function is required for resistance. Here we show that secondary Brca1 mutations are n...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-30710 | biostudies-arrayexpress
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