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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsRepurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurpos...

2025-11-13 | MTBLS13246 | MetaboLights
MetabolomicsAn integrated drug repositioning analysis for sarcopenia

Global population aging with increased longevity has incurred a higher prevalence of sarcopenia. Sarcopenia is characterized by age-related muscle/strength loss and is becoming a highly important public health issue. The development of sarcopenia increases the risk of various adverse health outco...

2026-01-09 | MTBLS9582 | MetaboLights
MetabolomicsMetabolite profiling of Malaysian Gracilaria edulis reveals Eplerenone as novel antibacterial compound for drug repurposing against MDR Bacteria
Not available
ORGANISM(S): Gracilaria edulis 
ST001839 | MetabolomicsWorkbench
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
UnknownA Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics.
Not available
S-EPMC12679946 | biostudies-literature
TranscriptomicsComparative genomic hybridization by array of east haploid and heterozygous essential deletion pools treated with compounds synergistic with fluconazole to identify sensitive and resistant mutants
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-07 | E-MTAB-394 | biostudies-arrayexpress
Proteomics20230905 ReFRAME drug repurposing collection DDA spectra
DDA analysis of 14,000 drugs in the ReFRAME drug repurposing collection. Positive and negative ionizations.
ORGANISM(S): Na 
MSV000092822 | MassIVE
GenomicsDrug repurposing strategy reveals Cobimetinib as a promising disease-modifying drug for Osteoarthritis
Drug repurposing strategy reveals Cobimetinib as a promising disease-modifying drug for Osteoarthritis
PRJNA1231107 | ENA
GenomicsSystems immunology-based drug repurposing framework to target inflammation in atherosclerosis [Tissue_RNA-seq]
Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis [Tissue_RNA-seq]
PRJNA957899 | ENA
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