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TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-14 | MTBLS13138 | MetaboLights
UnknownOxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice.
Not available
S-EPMC8000729 | biostudies-literature
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-17 | MTBLS13161 | MetaboLights
ProteomicsRestoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damag
Acetaminophen (APAP) is one of the most widely consumed and prescribed drugs. APAP overdose is one of the leading causes of intrinsic drug-induced liver injury (DILI), acute liver failure (ALF), and liver transplantation in the Western world. Mg2+, essential for health, plays a role in virtually ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036682 | Pride
Acetaminophen (apap) Cnnm4 Drug-induced liver damage (dili) Acute liver failulre (alf) Label free 
UnknownComprehensive analysis of high-throughput transcriptomics to distinguish drug-induced liver injury (DILI) phenotypes.
Not available
S-EPMC12408718 | biostudies-literature
UnknownCharacterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries.
Not available
S-EPMC10761448 | biostudies-literature
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
2024-06-18 | PXD053221 |
UnknownDynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.
Not available
S-EPMC5962642 | biostudies-literature
TranscriptomicsTargeted RNA-seq (TempO-Seq) of human induced pluripotent stem cell (hiPSC)-derived hepatocyte like cells (HLCs) treated with Nitrofurantoin against control condition
We wanted to investigate the transcriptional effect of Nitrofurantoin, a known drug induced liver injury (DILI)-compound, on hiPSC-derived HLCs. The goal was to identify which srress response pathways and biological processes are activated or altered in HLCs following Nitrofurantoin exposure. The co...
ORGANISM(S): Homo sapiens 
2025-08-09 | E-MTAB-15398 | biostudies-arrayexpress
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