Druggable genome

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BTO:0000214 (1)

Organisms

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synthetic construct (1)
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2012 (8)
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2015 (5)
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2009 (2)
2018 (2)
2016 (1)
2010 (1)

Metabolite Name

Acetyl-CoA_HMDB0001206 (1)
FAD_HMDB0001248 (1)
Coenzyme A_HMDB0001423 (1)
NADP_HMDB0000217 (1)
Stachyose_HMDB0003553 (1)
NADH_HMDB0001487 (1)
NAD_HMDB0000902 (1)
Uridine diphosphate-N-acetylglucosamine_HMDB0000290 (1)
Guanosine diphosphate mannose_HMDB0001163 (1)
Uridine diphosphate glucose_HMDB0000286 (1)
Taurocholic acid_HMDB0000036 (1)
Adenosine triphosphate_HMDB0000538 (1)
Raffinose_HMDB0003213 (1)
Taurodeoxycholic acid_HMDB0000896 (1)
Deoxycholic acid glycine conjugate_HMDB0000631 (1)
Adenosine diphosphate_HMDB0001341 (1)
Sucrose 6-Phosphate_No HMDB data (1)
Cholic acid_HMDB0000619 (1)
3-Oxocholic acid_HMDB0000502 (1)
Uridine 5'-diphosphate_HMDB0000295 (1)
Deoxycholic acid_HMDB0000626 (1)
S-Adenosylhomocysteine_HMDB0000939 (1)
Guanosine monophosphate_HMDB0001397 (1)
Maltitol_HMDB0002928 (1)
Trehalose_HMDB0000975 (1)
Deoxyadenosine monophosphate_HMDB0000905 (1)
Cyclic AMP_HMDB0000058 (1)
Cytidine monophosphate_HMDB0000095 (1)
Nonadecanoic acid_HMDB0000772 (1)
5'-Methylthioadenosine_HMDB0001173 (1)

IsPrivate

False (1)

Submitter Keywords

FROG (1)

First Public Date

2024 (22)
2025 (20)
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2019 (7)
2017 (6)
2014 (6)
2020 (5)
2018 (4)
2015 (2)
2016 (1)

Classification

viruses (1)
bacteria (1)

Modelling Approach

Constraint-based model (1)

Study type

Transcription profiling by array (17)
RNA-seq of coding RNA (9)
ChIP-seq (5)
Comparative genomic hybridization by array (3)
Methylation profiling by array (2)
ChIP-chip by tiling array (1)
Cell line - One-color microarray (1)
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Genotyping by array (1)
Other (1)
DNA-seq (1)
RNA-seq of coding RNA from single cells (1)
RNA-seq of total RNA (1)

Release Date

2025 (100)
2022 (93)
2024 (83)
2021 (75)
2020 (73)
2023 (70)
2018 (39)
2019 (38)
2016 (37)
2017 (36)
2015 (36)
2014 (26)
2012 (21)
2026 (15)
2013 (11)
2011 (7)
2010 (4)
2008 (3)
2009 (2)
2007 (1)

Lab affiliation

1Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA. Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA (1)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. (1)
Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Québec, QC, Canada Centre de recherche sur le cancer de l’Université Laval, Québec, QC, Canada PROTEO-Quebec Network for Research on Protein Function, Engineering, and Applications, Québec, QC, Canada Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec, QC, Canada (1)
Dana Farber Cancer Institute, Cancer Biology / Harvard Medical School, Biological Chemistry and Molecular Pharmacology (1)
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), Jena, Germany (1)
Department of Pharmacology University of Colorado Anschutz Medical Campus (1)
Departments of Immunology and Microbiology, Chemistry, Scripps Research, La Jolla, California 92037, United States (1)
Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France (1)
Novartis Institutes for BioMedical Research, Basel, Switzerland (1)
Professor. Neurological Surgery. Tong-Po Kan Chair in Neurological Surgery. UCSF Weill Institute for Neurosciences University of California San Francisco (UCSF) (1)
UCSF (1)
UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0AH, UK (1)
Univeristy of Rhode Island Dept of Biomedical and Pharmaceutical Sciences 7 Greenhouse Road, Kingston RI 02881 (1)
University of Zurich, Institute for Medical Virology, Switzerland (1)
Wellcome Centre for Cell Biology University of Edinburgh Michael Swann Building Max Born Crescent Edinburgh EH9 3BF Scotland, UK (1)

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Whole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights

The druggable genome and support for target identification and validation in drug development.

Not available

S-EPMC6321762 | biostudies-literature

High-throughput Oligopaint screen identifies druggable 3D genome regulators

PRJNA820829 | ENA

Evolutionary survey of druggable protein targets with respect to their subcellular localizations.

Not available

S-EPMC3730344 | biostudies-literature

Amplicon Sequencing of gRNAs from Druggable Genome CRISPR mutagenized Huh7.5.1 cells after live/dead selection with DENV2

Huh7.5.1 cells were stably transduced with lentiCas9-Blast (Addgene, #52962) and subsequently selected using Blasticidin. Then, Huh7.5.1 cells that constitutively express Cas9 were transduced with lentiGuide-Puro from the druggable genome library at MOI 0.3. Cells were then selected with puromycin, ...

ORGANISM(S): Homo sapiens

2024-12-29 | E-MTAB-14693 | biostudies-arrayexpress

Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome-Wide Mendelian Randomization Analysis.

Not available

S-EPMC12417969 | biostudies-literature

Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery.

Not available

S-EPMC12154160 | biostudies-literature

Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer's disease.

Not available

S-EPMC10579488 | biostudies-literature

Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment.