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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
UnknownFinding Druggable Sites in Proteins Using TACTICS.
Not available
S-EPMC8631419 | biostudies-literature
UnknownDruggable Allosteric Sites in β-Propeller Lectins.
Not available
S-EPMC9298952 | biostudies-literature
UnknownSpatiotemporal identification of druggable binding sites using deep learning.
Not available
S-EPMC7591901 | biostudies-literature
UnknownCryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.
Not available
S-EPMC4794384 | biostudies-literature
UnknownGraph Attention Site Prediction (GrASP): Identifying Druggable Binding Sites Using Graph Neural Networks with Attention.
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S-EPMC10402091 | biostudies-literature
UnknownGraph Attention Site Prediction (GrASP): Identifying Druggable Binding Sites Using Graph Neural Networks with Attention.
Not available
S-EPMC11182664 | biostudies-literature
UnknownIdentifying promising druggable binding sites and their flexibility to target the receptor-binding domain of SARS-CoV-2 spike protein.
Not available
S-EPMC10023212 | biostudies-literature
UnknownIn Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
Not available
S-EPMC7825788 | biostudies-literature
UnknownRevealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites.
Not available
S-EPMC11888411 | biostudies-literature
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