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MetabolomicsSphingolipid-dependent Dscam sorting regulates axon segregation
Neurons are highly polarized cells with distinct protein compositions in axonal and dendritic compartments. Cellular mechanisms controlling polarized protein sorting have been described for mature nervous system but little is known about the segregation in newly differentiated neurons. In a forward ...
2019-03-29 | MTBLS825 | MetaboLights
TranscriptomicsUltra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing
The Drosophila melanogaster gene Dscam can generate thousands of different ectodomains via mutual exclusive splicing of three large exon clusters. The isoform diversity plays a profound role in both neuronal wiring and pathogen recognition. However, it remained unexplored how many isoforms are indee...
ORGANISM(S): Drosophila melanogaster 
2013-06-27 | E-GEOD-45167 | biostudies-arrayexpress
GenomicsNuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation
Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation
PRJNA505631 | ENA
TranscriptomicsNuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation
DSCAM and DSCAML1 are immunoglobulin and cell adhesion-type receptors serving important neurodevelopmental functions including control of axon growth, branching, neurite self-avoidance and neuronal cell death. The signal transduction mechanisms or effectors of DSCAM receptors however, remain poorly ...
ORGANISM(S): Homo sapiens 
2019-02-08 | GSE122568 | GEO
GenomicsIncreased Endothelial Sclerostin Caused by Elevated DSCAM Mediates Multiple Trisomy 21 (Down Syndrome) Phenotypes
Increased Endothelial Sclerostin Caused by Elevated DSCAM Mediates Multiple Trisomy 21 (Down Syndrome) Phenotypes
PRJNA1064888 | ENA
GenomicsDSCAM-AS1-driven proliferation of breast cancer cells involves regulation of alternative exon splicing and 3’-end usage
DSCAM-AS1-driven proliferation of breast cancer cells involves regulation of alternative exon splicing and 3’-end usage
PRJNA632880 | ENA
TranscriptomicsDSCAM-AS1-driven proliferation of breast cancer cells involves regulation of alternative exon splicing and 3’-end usage
Background: DSCAM-AS1 is a cancer-related long noncoding RNA with higher expression levels in Luminal A, B and HER2-positive Breast Cancer (BC), where its expression is strongly dependent on Estrogen Receptor Alpha (ERα). Method: To decipher its function, DSCAM-AS1 expression was measured by qRT-PCR...
ORGANISM(S): Homo sapiens 
2020-05-15 | GSE150591 | GEO
UnknownCell autonomy of DSCAM function in retinal development.
Not available
S-EPMC3246579 | biostudies-literature
UnknownDSCAM-AS1 promotes the development of prostate cancer.
Not available
S-EPMC11009176 | biostudies-literature
UnknownDysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.
Not available
S-EPMC8873012 | biostudies-literature
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