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GenomicsThe dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins
The dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins
PRJNA771393 | ENA
UnknownThe dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins.
Not available
S-EPMC9262589 | biostudies-literature
TranscriptomicsThe dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome
Purpose: The purpose of this experiment is to expand the repertoire of C. elegans edited transcripts and identify the roles of ADR-1 as indirect regulator of editing and ADR-2 as the only active deaminase in vivo. Methods: Strand-specific RNA sequencing of wild-type and adr mutant worms, followed by...
ORGANISM(S): Caenorhabditis elegans 
2014-01-20 | E-GEOD-51556 | biostudies-arrayexpress
UnknownMD simulations of the dsRBP DGCR8 reveal correlated motions that may aid pri-miRNA binding.
Not available
S-EPMC2895372 | biostudies-literature
GenomicsFunctional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection
In Drosophila, the siRNA pathway is initiated when exogenous or endogenous double stranded RNA (dsRNA) is processed into siRNAs by Dicer-2 (Dcr-2) and a dsRNA-binding protein (dsRBP) cofactor called Loquacious (Loqs). The siRNAs are then loaded onto Argonaute-2 (Ago2) protein by the action of Dcr-2 ...
ORGANISM(S): Drosophila melanogaster 
2012-03-16 | GSE36449 | GEO
TranscriptomicsFunctional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection
In Drosophila, the siRNA pathway is initiated when exogenous or endogenous double stranded RNA (dsRNA) is processed into siRNAs by Dicer-2 (Dcr-2) and a dsRNA-binding protein (dsRBP) cofactor called Loquacious (Loqs). The siRNAs are then loaded onto Argonaute-2 (Ago2) protein by the action of Dcr-2 ...
ORGANISM(S): Drosophila melanogaster 
2012-03-16 | E-GEOD-36449 | biostudies-arrayexpress
UnknownCharacterization of tumor microenvironment and tumor immunology based on the double-stranded RNA-binding protein related genes in cervical cancer.
Not available
S-EPMC10515034 | biostudies-literature
GenomicsThe dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins
Here, we have characterized the role of the RNA-binding protein Staufen2, a potential Ago interactor, in RNP assembly. Staufen2 depletion resulted in the upregulation of Ago1/2 and the RISC effector proteins Ddx6 and Dcp1a. This upregulation was accompanied by the displacement of Ago2 from processin...
ORGANISM(S): Rattus norvegicus 
2022-05-31 | GSE185935 | GEO
UnknownLoqs and R2D2 act sequentially in the siRNA pathway in Drosophila.
Not available
S-EPMC2919300 | biostudies-literature
UnknownColeopteran-specific StaufenC functions like Drosophila melanogaster Loquacious-PD in dsRNA processing.
Not available
S-EPMC8677030 | biostudies-literature
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