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ProteomicsIdentification of whole-cell dsRNA-binding proteins by phase separation
Interactions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA. The identification of dsRNA-binding proteins (dsRBPs) is key; however, it has long been challenging to purify dsRBPs f...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-10-17 | PXD048971 | Pride
Dsrna-binding domain Dsrna-binding protein capture Armadillo/beta-catenin-like repeats Dsrna-binding proteome Dsrna-binding proteins 
TranscriptomicsTissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-wide Elucidation of its Target mRNAs
RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulation functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding proteins with their targets is regulated through changing sub-cellular distribution, post-tr...
ORGANISM(S): Homo sapiens 
2010-05-04 | E-GEOD-20001 | biostudies-arrayexpress
GenomicsCharacterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
Characterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
PRJNA1224849 | ENA
TranscriptomicsThe dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome
Purpose: The purpose of this experiment is to expand the repertoire of C. elegans edited transcripts and identify the roles of ADR-1 as indirect regulator of editing and ADR-2 as the only active deaminase in vivo. Methods: Strand-specific RNA sequencing of wild-type and adr mutant worms, followed by...
ORGANISM(S): Caenorhabditis elegans 
2014-01-20 | E-GEOD-51556 | biostudies-arrayexpress
UnknownIdentification of whole-cell dsRNA-binding proteins by phase separation.
Not available
S-EPMC11312991 | biostudies-literature
TranscriptomicsDicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals
Drosophila Dicer-1 produces microRNAs (miRNAs) from pre-miRNA, whereas Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. loquacious (loqs) encodes three Dicer partner proteins, Loqs-PA, Loqs-PB, and, Loqs-PD, generated by alternative splicing. To understand the function of each Loqs...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-37443 | biostudies-arrayexpress
OtherCharacterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
Double-stranded RNA (dsRNA) binding proteins (dsRBPs) play crucial roles in various cellular processes, especially in the innate immune response. Comprehensive characterization of dsRBPs is essential to understand the intricate mechanisms for dsRNA sensing and response. Traditional methods have pred...
ORGANISM(S): Homo sapiens 
2025-03-04 | GSE289807 | GEO
UnknownCharacterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator.
Not available
S-EPMC11985509 | biostudies-literature
ProteomicsCharacterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
Double-stranded RNA (dsRNA) binding proteins (dsRBPs) play crucial roles in various cellular processes, especially in the innate immune response. Comprehensive characterization of dsRBPs is essential to understand the intricate mechanisms for dsRNA sensing and response. Traditional methods have pred...
ORGANISM(S): Homo Sapiens 
2024-04-23 | PXD051654 |
UnknownSpecific requirement of DRB4, a dsRNA-binding protein, for the in vitro dsRNA-cleaving activity of Arabidopsis Dicer-like 4.
Not available
S-EPMC3062185 | biostudies-literature
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