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TranscriptomicsTranscription profiling of chicken B cell lymphoma (DT40) cell lines.
Global gene expression profiling of the avian B-lymphoma DT40 cell line was used as a model to differentiate among Btk KO and Btk KO cells reconstituted with human Btk. Differences in the gene expression pattern showed statistically significant changes between parental DT40 and all the Btk KO cell p...
ORGANISM(S): Gallus gallus 
2008-11-13 | E-GEOD-11597 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken histone H1 null mutant cells
In chicken DT40 cells, there are six linker histone H1 variants and 12 of coding genes. We have previously reported of 11 out of 12 H1 knock out DT40 cells (Takami et al., Genes to Cell 1997 [PMID:9491804]) but complete H1 null DT40 cells could not established, so far. We identified one of the H1 va...
ORGANISM(S): Gallus gallus 
2008-11-04 | E-GEOD-8483 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken Pax5 deficient DT40 B cell line
PAx5 is indispensible for the committment if early lymphoid progenitors to the B cell lineage as well as for the development and maintenance of B cells. To better understand the functional importance of Pax5 in the later stages of B cell development and investigate the targets of Pax5 regulation, w...
ORGANISM(S): Gallus gallus 
2005-04-17 | E-MEXP-270 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken histone H1 variant deletion DT40 mutant cell
There are six histone H1 variant in chicken. 01H1/02H1/03H1/.10H1/H1L and H1R. In those variant we forcused on H1L and H1R those molecule were most similar H1 among six H1 variants. we established linker histone H1L and H1R deleted mutant in chicken B-cell derived DT40 cell and assay gene expression...
ORGANISM(S): Gallus gallus 
2008-11-08 | E-GEOD-5114 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression between wild-type and PTIP deficient chicken DT40 B cells
PTIP (Pax2 transactivation domain-interacting protein) is a nuclear protein containing six BRCT domains. It has been shown that PTIP affects gene expression by controlling the activity of the transcription factor Pax2 and histone H3 lysine 4 methyltransferase complexes. In addition to its role in tr...
ORGANISM(S): Gallus gallus 
2009-10-27 | E-GEOD-18778 | biostudies-arrayexpress
TranscriptomicsEvaluation of the chicken transcriptome by SAGE of B cell and the DT40 cell line
These libraries represent total RNA from bursal tissue of 20 day old CB-inbred chicks and the ALV induced bursal cell line DT40 Cre1 cells. Keywords = chicken transcriptome SAGE Bursal cell DT40
ORGANISM(S): Gallus gallus 
2004-10-06 | E-GEOD-1817 | biostudies-arrayexpress
TranscriptomicsRNA-seq of H3.3 knockout and wild type chicken DT40 cells
RNA-seq was performed for transcriptional analysis of wild-type DT40 cells (Gallus gallus, B-cell line) and a H3.3 knockout line (h3.3a-/-, h3.3b-/-). H3.3 is a H3 histone variant encoded on two genes (H3.3A and H3.3B) in chickens.
ORGANISM(S): Gallus gallus 
2014-08-31 | E-MTAB-2754 | biostudies-arrayexpress
TranscriptomicsExpression profiling of DT40 chicken B cell line by RNA-seq
A single replicate of exponentially growing DT40 CL18 chicken B lymphoma cells were harvested and extracted RNA was subjected to Illumina GAIIx paired-end sequencing to determine global gene expression. Single replicate RNA-seq expression analysis of DT40 cells.
ORGANISM(S): Gallus gallus 
2015-09-04 | E-GEOD-58766 | biostudies-arrayexpress
ProteomicsDT40 whole cell proteome (SILAC)
SILAC quantitative proteomics was used to compare the whole cell proteomes of the differentially SILAC-labelled wild-type and acentrosomal (stil KO) DT40 cell lines.
ORGANISM(S): Gallus gallus (Chicken) 
2019-05-30 | PXD011248 | Pride
G. gallus Silac Dt40 
TranscriptomicsProfile of gene expression signatures on DT40 cell for bursal-derived peptides
To further elucidate the mechanism of bursal-derived bioactive peptides on avian B cell proliferation on the broad molecular level, we have employed whole genome microarray expression profiling as a discovery platform to examine gene expression patterns during BP5 and BSP-II treatment in DT40 cell c...
ORGANISM(S): Gallus gallus 
2011-07-06 | E-GEOD-30396 | biostudies-arrayexpress
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