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MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
MetabolomicsMetabolomic assessment of acute cholestatic injuries induced by thioacetamide and by bile duct ligation, and the protective effects of Huang-Lian-Jie-Du-Decoction
Huang-Lian-Jie-Du-Decoction, a traditional Chinese formula, has been reported to protect liver from various injuries. Two cholestasis models of rats induced by thioacetamide and by bile duct ligation were established and treated with Huang-Lian-Jie-Du-Decoction. Nuclear Magnetic Resonance-based urin...
2016-06-08 | MTBLS149 | MetaboLights
MetabolomicsDifferential effects of Huang-Lian-Jie-Du Decoction on Alzheimer’s disease and normal rats

Introduction: Huang-Lian-Jie-Du Decoction (HLJDD), a botanical drug used in traditional medicine, has been used in the management of Alzheimer’s disease (AD). However, the mechanisms underlying its preventive effects remain inadequately understood, particularly due to the absence of metabolomic s...

2025-11-04 | MTBLS13256 | MetaboLights
GenomicsBacillus sp. DU-106
Bacillus sp. DU-106 Genome sequencing
PRJNA432450 | ENA
GenomicsAvihepatovirus A strain:Du/Egy/Benha/2020/DHAV-1
Avihepatovirus A strain:Du/Egy/Benha/2020/DHAV-1 Genome sequencing
PRJNA1028634 | ENA
Transcriptomics3prime RNA-seq of human prostate cancer cell line DU-145 treated with Senexin A
Human prostate cancer cell line DU-145 was treated with Senexin A or DMSO control for 48h before performing 3-prime RNAseq.
ORGANISM(S): Homo sapiens 
2016-10-28 | E-MTAB-5150 | biostudies-arrayexpress
MetabolomicsMetabolic Responses of a Model Green Microalga Euglena gracilis to Different Environmental Stresses

Euglena gracilis, a green microalga known as a potential candidate for jet fuel producers and new functional food resources, is highly tolerant to antibiotics, heavy metals and other environmental stresses. Its cells contain many high-value products, including vitamins, amino acids, pigm...

2022-08-16 | MTBLS2878 | MetaboLights
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-GEOD-55728 | biostudies-arrayexpress
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsA microfluidics-based in vitro model of the gastrointestinal human-microbe interface
Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. Here we present a modular, microfluidics-based model (HuMiX, human–microbial crosstalk), w...
2017-07-28 | MTBLS328 | MetaboLights
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