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TranscriptomicsArrayCGH mapping of the recurrent 3q26.3-q27 amplifications in lung Squamous Cell Carcinoma (SCC)
To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. Chromosome 3 aberrations are indeed among the most frequent alterations in lung SCC and correlate with SCC patient's poor prog...
ORGANISM(S): Homo sapiens 
2010-02-09 | E-GEOD-15079 | biostudies-arrayexpress
TranscriptomicsSOX2 is a new oncogene activated by the recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma
This SuperSeries is composed of the following subset Series: GSE14859: ArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC) GSE14883: SOX2 overexpression effect on human lung squamous cells GSE15079: ArrayCGH mapping of the recurrent 3q26.3-q27mplifications in lung Squa...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-15080 | biostudies-arrayexpress
TranscriptomicsArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC)
To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. These aberrations are indeed among the most frequent aberrations in lung SCC and correlate with SCC patient's poor prognosis. ...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14859 | biostudies-arrayexpress
TranscriptomicsSOX2 overexpression effect on human lung squamous cells
We have identified SOX2 as a new oncogene and a likely driver of recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma. SOX2 is a crucial transcription factor implicated in Embryonic and Neural Stem Cells, that we found widely activatd in human lung SCC. This part of the study aimed at an...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14883 | biostudies-arrayexpress
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