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TranscriptomicsEndogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
Small interfering RNAs (siRNAs) direct RNA interference (RNAi) in eukaryotes. In flies, somatic cells produce siRNAs from exogenous double-stranded RNA as a defense against viral infection. Here, we identify 21-nt long, endogenous siRNAs (endo-siRNAs) corresponding to transposons and heterochromatic...
ORGANISM(S): Drosophila melanogaster 
2008-04-10 | E-GEOD-11019 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO ChIP-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47878 | biostudies-arrayexpress
TranscriptomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO RNA-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47883 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO 5hmC-capture-seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47892 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO Methyl-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47890 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO Methyl-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47893 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO ChIP-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47887 | biostudies-arrayexpress
ProteomicsA proteomic classifier panel for early screening of colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042639 | Pride
Plasma proteome biomarker 
ProteomicsA proteomic classifier panel for early screening of colorectal cancer part II
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042652 | Pride
Plasma proteome biomarker 
ProteomicsGypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism
Gypenosides is a traditional drug for the treatment of metabolic disorders. Recent studies have confirmed its anti-nonalcoholic fatty liver disease (NAFLD) effects, but the underlying mechanisms are still not fully understood. The purpose of this study was to explore the protective mechanism of gype...
ORGANISM(S): Mus Musculus 
2022-12-14 | PXD038829 |
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