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TranscriptomicsNext-generation sequencing facilitates quantitative analysis of AcKLF5 and unAcKLF5 transcriptomes in xenografts of DU-145 cell line
KLF5 possesses both tumor-suppressing and tumor-promoting activities, though the mechanism controlling these opposing functions is unknown. In cultured non-cancerous epithelial cells, KLF5 converts from pro-proliferative to anti-proliferative activity upon TGFβ-induced acetylation, which sequential...
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-56343 | biostudies-arrayexpress
TranscriptomicsFunctional Annotation of the Bovine Genome
The goal of the proposed project is to generate high-quality detailed transcript and chromatin status datasets from a comprehensive set of bovine tissues, developmental stages, and cells through a set of rationally selected assays. Experimental data generated by the project have been analyzed using ...
ORGANISM(S): Bos taurus 
2022-10-13 | E-MTAB-12052 | biostudies-arrayexpress
UnknownDistribution of fragile X mental retardation 1 CGG repeat and flanking haplotypes in a large Chinese population.
Not available
S-EPMC4444158 | biostudies-literature
UnknownThe inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Not available
S-EPMC9361523 | biostudies-literature
UnknownEnzyme-mediated aminoglycoside resistance without target mimicry.
Not available
S-EPMC12378234 | biostudies-literature
MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
TranscriptomicsExpression in HepG2 cells with overexpression of TMPRSS6 or its mutant version.
TMPRSS6 is a type II transmembrane serine protease and is revealed by our work to be part of a low-iron sensing pathway. When animal gets iron deficient, TMPRSS6 is required to shut off hepcidin gene, so as to allow iron to be uptaken from GI tract. The mutant mouse, which was generated by ENU mutag...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10591 | biostudies-arrayexpress
UnknownThe chest X-ray score baseline in predicting continuous oxygen therapy failure in low-risk aged patients after thoracic surgery.
Not available
S-EPMC11009605 | biostudies-literature
MetabolomicsMetabolic Responses of a Model Green Microalga Euglena gracilis to Different Environmental Stresses

Euglena gracilis, a green microalga known as a potential candidate for jet fuel producers and new functional food resources, is highly tolerant to antibiotics, heavy metals and other environmental stresses. Its cells contain many high-value products, including vitamins, amino acids, pigm...

2022-08-16 | MTBLS2878 | MetaboLights
UnknownTamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption.
Not available
S-EPMC12773634 | biostudies-literature
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