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TranscriptomicsmicroRNA expression in human tonsillar B cell populations
small RNA profiles of 6 human tonsillar B cell populatios (naive B cells, pre-germinal center B cells, centrocytes, centroblasts, memory B cells, and plasma cells) were determined by deep sequencing. These samples were compared to mouse developing lymphocytes, various hematopoietic cell lineages, a...
ORGANISM(S): Homo sapiens 
2010-07-23 | E-GEOD-23090 | biostudies-arrayexpress
TranscriptomicsA mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Igh/Myc translocations underlie both sporadic Burkitt lymphoma (BL) and the endemic clinical form affecting African children infected with malaria. However, while sporadic translocations decapitate Myc from 5' proximal regulatory elements, most endemic events occur hundreds of kilobases away from My...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48514 | biostudies-arrayexpress
TranscriptomicsRegulation of microRNA Expression and Abundance during Lymphopoiesis
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We used deep-sequencing to characterize the microRNome from most developing lymphocytes, various hematopoietic cell lineages, and representative m...
ORGANISM(S): Mus musculus 
2010-06-07 | E-GEOD-21630 | biostudies-arrayexpress
TranscriptomicsExpression profiling of IL6 and Myc TG mouse plasmacytoma
To identify differentially expressed genes in mouse IL6 and Myc double TG plasmacytoma, total RNAs from mouse plasmacytoma generated from IL6 + Myc TG mice were applied to NIAID mouse gene expression arrays. The transcriptome in IL6+ Myc TG mouse PCT was compared to transcriptome in IL6 TG mouse PCT...
ORGANISM(S): Mus musculus 
2010-01-31 | E-GEOD-19336 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling in mouse plasma cell tumor precursor and bystander cells revels potential intervention targets for plasma-cell neoplasia
We extracted nascent plasma cell tumor (PCT) cells from within inflammatory granulomas (OG) isolated from intraperitoneal pristane-injected BALB/c.iMyc Eμ mice at five different time points during tumor progression. We used laser capture micro-dissection to collect incipient PCT cells and analyzed ...
ORGANISM(S): Mus musculus 
2011-12-02 | E-GEOD-34078 | biostudies-arrayexpress
TranscriptomicsB cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
The antibody gene mutator AID promiscuously damages oncogenes and B cell identity genes leading to chromosomal translocations and tumorigenesis. Why non-immunoglobulin loci are susceptible to AID activity is unknown. Here we study AID-mediated lesions in the context of nuclear architecture and the B...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62063 | biostudies-arrayexpress
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