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ProteomicsInterleukin 13 disrupts type 2 pneumocyte stem cell activity
Chronic lung disease is increasing in prevalence and there is urgent need to advance our understanding of human lung biology in order to improve diagnosis and current treatments. The Th2 inflammatory cytokine Interleukin 13 (IL13) has been associated with both obstructive and fibrotic lung diseases...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2020-06-05 | PXD013006 | Pride
Idiopathic pulmonary fibrosis Secretome Alveolar epithelial cell 
UnknownPhase II study of selumetinib, an orally active inhibitor of MEK1 and MEK2 kinases, in KRASG12R-mutant pancreatic ductal adenocarcinoma.
Not available
S-EPMC8068685 | biostudies-literature
TranscriptomicsTranscription profiling of human multifocal lesions from patients with in-transit extremity melanoma to determine if gene expression is hetereogenous in all lesions
An evaluation of multifocal lesions from patients with in-transit extremity melanoma to determine if all lesions from a patient harbor homogeneous patterns of gene expression; Gene expression profiling studies can help guide treatment for cancer patients by providing tools in the form of gene-expres...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-10282 | biostudies-arrayexpress
ProteomicsLayers of regulation on cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, transcription factors (TFs) regulate the periodic expression of many genes during the cell cycle, including gene products required for progression through cell-cycle events. Experimental evidence coupled with quantitative models suggest that a network o...
ORGANISM(S): Saccharomyces Cerevisiae 
PXD010937 | panorama
TranscriptomicsTrancription profling of In-transit extremity melanoma II lesions
An evaluation of biopsies from patients with in-transit extremity melanoma who have been treated with melphalan in the setting of isolated limb infusion Gene expression profiles were obtained from 52 lesions across 28 patients and evaluated for expression values that correlated with response to melp...
ORGANISM(S): Homo sapiens 
2010-03-09 | E-GEOD-19293 | biostudies-arrayexpress
TranscriptomicsIn-transit extremity melanoma III
An evaluation of biopsies from patients with in-transit extremity melanoma who have been treated with melphalan in the setting of isolated limb infusion or isolated limb perfusion. Gene expression profiles were obtained from 21 lesions across 19 patients and evaluated for expression that correlated ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-34599 | biostudies-arrayexpress
TranscriptomicsPhase II trial melphalan ILI plus ADH-1 for treatment of in-transit extremity melanoma
An evaluation of biopsies from patients with in-transit extremity melanoma who have been treated with ADH-1 followed by melphalan in the setting of isolated limb infusion Gene expression profiles were obtained from 28 lesions across 15 patients and evaluated for expression values that correlated wit...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-22968 | biostudies-arrayexpress
UnknownGPC3-mediated metabolic rewiring of diabetic mesenchymal stromal cells enhances their cardioprotective functions via PKM2 activation.
Not available
S-EPMC11490746 | biostudies-literature
UnknownTranslational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Not available
S-EPMC5070554 | biostudies-literature
ProteomicsUrinary Proteome of Chronic Kidney Disease of Unknown Etiology (CKDu)
2 mL of preserved urine samples were precipitated overnight with 5 mL of ice-cold acetone, pellets were washed 70% acetone resuspended in 5% SDS followed by trypsin digestion of up to 100 ugs of each sample using an S-trap. One-third of tryptic peptides were microflow LC-MS/MS using an ACQUITY UPLC ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-11 | MSV000090513 | MassIVE
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