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TranscriptomicsGenetic ancestry and natural selection drive population differences in immune responses to pathogens in humans
Individuals from different populations vary considerably in their susceptibility to immune-related diseases. To understand how genetic variation and natural selection contribute to these differences, we tested for the effects of African versus European ancestry on the transcriptional response of pri...
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-81046 | biostudies-arrayexpress
TranscriptomicsWidespread shortening of 3’ untranslated regions and increased exon inclusion characterize the human macrophage response to infection [mRNA]
Changes in gene regulation have long been known to play important roles in both innate and adaptive immune responses. However, post-transcriptional mechanisms involved in mRNA processing have been poorly studied despite emerging examples of their role as regulators of immune defenses. We sought to i...
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-73502 | biostudies-arrayexpress
TranscriptomicsWidespread shortening of 3â?? untranslated regions and increased exon inclusion characterize the human macrophage response to infection [miRNA]
Changes in gene regulation have long been known to play important roles in both innate and adaptive immune responses. However, post-transcriptional mechanisms involved in mRNA processing have been poorly studied despite emerging examples of their role as regulators of immune defenses. We sought to i...
ORGANISM(S): Homo sapiens 
2016-09-06 | E-GEOD-73478 | biostudies-arrayexpress
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