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ProteomicsMouse Sperm TMT MCP
Mouse Sperm Proteomic Profiling - University of Newcastle - Dr. Matt Dun
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-06-24 | MSV000082497 | MassIVE
ProteomicsBlockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies
Mutations in the type III receptor tyrosine kinase FLT3 are frequent in patients with acute myeloid leukemia (AML) and are associated with a poor prognosis. AML is characterized by the overproduction of reactive oxygen species (ROS), which can induce cysteine oxidation in redox-sensitive signaling p...
ORGANISM(S): Homo sapiens (Human) 
2023-05-03 | PXD032104 | Pride
Redox Pdx Itraq Leukaemia Aml 
ProteomicsCrocodile Sperm Proteome
In a reproductive strategy that is considered unique to the mammalian lineage, spermatozoa must undergo a series of physiological changes, termed capacitation, in the female reproductive tract prior to developing their capacity to fertilize an ovum. Here, we have employed a comparative proteomic str...
ORGANISM(S): Crocodylus Porosus (ncbitaxon:8502) 
2018-04-08 | MSV000082258 | MassIVE
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
ProteomicsThe reproductive toxicant acrylamide modulates the mouse epididymal proteome to drive alterations to the sperm epigenome and dysregulate embryo development.
Paternal exposure to a range of environmental and lifestyle factors elicits distinct changes to the sperm sncRNA profile; modifications that have significant post-fertilization consequences. Despite this knowledge, there remains limited mechanistic understanding of how paternal exposures effect the ...
ORGANISM(S): Mus Musculus 
2021-10-08 | PXD022876 | panorama
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